Esomeprazole doesn't improve asthma symptoms
Clinical Question
Does esomeprazole improve symptoms and quality of life in patients with asthma?
Bottom Line
In this study, esomeprazole (Nexium) was no better than placebo in improving peak expiratory flow, asthma symptoms, or quality of life in patients with stable asthma. Furthermore, esomeprazole was no better than placebo in patients with reflux, either. (LOE = 2b-)
Reference
Kiljander TO, Harding SM, Field SK, et al. Effects of esomeprazole 40 mg twice daily on asthma: a randomized placebo-controlled trial. Am J Respir Crit Care Med 2006;173:1091-1097. [PMID:16357331]
Study Design
Randomized controlled trial (double-blinded)
Funding
Industry
Allocation
Uncertain
Setting
Outpatient (any)
Synopsis
After completing a run-in period of 11 days to 14 days, these researchers randomized patients with stable asthma already taking adequate control medications (inhaled corticosteroids and/or leukotriene inhibitors) to receive 16 weeks of 40 mg esomeprazole twice daily or placebo. They don't describe if the allocation was concealed. As a planned subanalysis of this study, the investigators also classified patients by the presence or absence of gastroesophageal reflux disease (GERD) or nocturnal symptoms. The authors don't describe if they used an intention to treat approach to evaluate the outcomes: peak expiratory flow rates, symptoms, and quality of life. At the conclusion of the study, there was no significant difference in the main outcomes, use of rescue medication, or other secondary outcomes. Of the various subgroups, only the group with both GERD and nocturnal symptoms had a small increase in peak expiratory flow rate, but no they showed improvement on any of the clinically relevant outcomes. The manufacturer of esomeprazole designed and funded this study. Given the silence on key methodologic issues (masked allocation, intention to treat, and so forth), these data may be biased in favor of the intervention group, making this a truly negative study.
Citation
Barry, Henry, et al., editors. "Esomeprazole Doesn't Improve Asthma Symptoms." EE+ POEM Archive, John Wiley & Sons, 2024. Evidence Central, evidence.unboundmedicine.com/evidence/view/infoPOEMs/426806/all/Esomeprazole_doesn't_improve_asthma_symptoms.
Esomeprazole doesn't improve asthma symptoms. In: Barry HH, Ebell MHM, Shaughnessy AFA, et al, eds. EE+ POEM Archive. John Wiley & Sons; 2024. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426806/all/Esomeprazole_doesn't_improve_asthma_symptoms. Accessed November 7, 2024.
Esomeprazole doesn't improve asthma symptoms. (2024). In Barry, H., Ebell, M. H., Shaughnessy, A. F., & Slawson, D. C. (Eds.), EE+ POEM Archive. John Wiley & Sons. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426806/all/Esomeprazole_doesn't_improve_asthma_symptoms
Esomeprazole Doesn't Improve Asthma Symptoms [Internet]. In: Barry HH, Ebell MHM, Shaughnessy AFA, Slawson DCD, editors. EE+ POEM Archive. John Wiley & Sons; 2024. [cited 2024 November 07]. Available from: https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426806/all/Esomeprazole_doesn't_improve_asthma_symptoms.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Esomeprazole doesn't improve asthma symptoms
ID - 426806
ED - Barry,Henry,
ED - Ebell,Mark H,
ED - Shaughnessy,Allen F,
ED - Slawson,David C,
BT - EE+ POEM Archive
UR - https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426806/all/Esomeprazole_doesn't_improve_asthma_symptoms
PB - John Wiley & Sons
DB - Evidence Central
DP - Unbound Medicine
ER -