Colon cancer screening may be beneficial for Lynch syndrome
Is cancer screening effective for individuals with Lynch syndrome?
There is fair evidence, based on observational trials only, to support colorectal cancer screening in individuals with Lynch syndrome, but the optimal age of initiation and optimal frequency of screening is unknown. Insufficient evidence is available to recommend screening for other cancers. (LOE = 2a)
Lindor NM, Petersen GM, Hadley DW, et al. Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome. A systematic review. JAMA 2006;296:1507-17. [PMID:17003399]
Lynch syndrome is an autosomal dominant disorder affecting individuals resulting in an increased risk of early onset colon cancer (hereditary nonpolyposis colorectal cancer) and cancers of the endometrium, ovary, hepatobiliary system, small intestine, kidney, and ureter. These investigators thoroughly searched multiple sources, including PubMed, the Cochrane Database of Systematic Reviews, reference lists, and communication with researchers in the field for English-language articles evaluating the effectiveness of cancer screening. Only prospective and retrospective observational trials were found, showing that individuals undergoing regular screening have a reduced mortality rate compared with control patients not screened. High-quality evidence from randomized trials is not currently available. Overall, the authors believe that the evidence supports recommending screening for colon cancer. There is insufficient evidence, however, to support screening for other types of cancer in individuals with Lynch syndrome. The frequency of colorectal cancer screening, and the optimal age at which to begin it, is unknown.
Barry, Henry, et al., editors. "Colon Cancer Screening May Be Beneficial for Lynch Syndrome." EE+ POEM Archive, John Wiley & Sons, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/infoPOEMs/426750/all/Colon_cancer_screening_may_be_beneficial_for_Lynch_syndrome.
Colon cancer screening may be beneficial for Lynch syndrome. In: Barry HH, Ebell MHM, Shaughnessy AFA, et al, eds. EE+ POEM Archive. John Wiley & Sons; 2019. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426750/all/Colon_cancer_screening_may_be_beneficial_for_Lynch_syndrome. Accessed September 21, 2023.
Colon cancer screening may be beneficial for Lynch syndrome. (2019). In Barry, H., Ebell, M. H., Shaughnessy, A. F., & Slawson, D. C. (Eds.), EE+ POEM Archive. John Wiley & Sons. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426750/all/Colon_cancer_screening_may_be_beneficial_for_Lynch_syndrome
Colon Cancer Screening May Be Beneficial for Lynch Syndrome [Internet]. In: Barry HH, Ebell MHM, Shaughnessy AFA, Slawson DCD, editors. EE+ POEM Archive. John Wiley & Sons; 2019. [cited 2023 September 21]. Available from: https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426750/all/Colon_cancer_screening_may_be_beneficial_for_Lynch_syndrome.
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TY - ELEC T1 - Colon cancer screening may be beneficial for Lynch syndrome ID - 426750 ED - Barry,Henry, ED - Ebell,Mark H, ED - Shaughnessy,Allen F, ED - Slawson,David C, BT - EE+ POEM Archive UR - https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426750/all/Colon_cancer_screening_may_be_beneficial_for_Lynch_syndrome PB - John Wiley & Sons DB - Evidence Central DP - Unbound Medicine ER -