Continued BP control important in T2DM (UKPDS)
Clinical Question
Is the benefit of blood pressure control in type 2 diabetes mellitus sustained after 10 years?
Bottom Line
Good control of blood pressure (defined as < 150/85 in this study) in patients with diabetes is critical, and this study reinforces the importance of maintaining good blood pressure control over time. (LOE = 2b)
Reference
Holman RR, Paul SK, Bethel MA, Neil HA, Matthews DR. Long-term follow-up after tight control of blood pressure in type 2 diabetes. N Engl J Med 2008;359(15):1565-1576. [PMID:18784091]
Study Design
Cohort (prospective)
Funding
Government
Setting
Outpatient (any)
Synopsis
This is a follow-up to the landmark United Kingdom Prospective Diabetes Study trial. Initially, 1148 patients with newly diagnosed type 2 diabetes mellitus and hypertension were randomized in a 2-to-1 ratio to tight blood pressure control with captopril or atenolol (target blood pressure of < 150/85 mm Hg) or less tight control without either drug (< 180/105 mm Hg). The mean age of patients was 56 years and 87% were white. The study found important reductions in any diabetes-related end point (including death), stroke, and microvascular disease among patients randomized to the tight control group over the 8-year mean follow-up period. At the end of the study, patients who had not died, emigrated, or dropped out (n = 884) were followed up for another 10 years. At the end of the 10-year period, 372 patients had completed post-trial monitoring. Over the 10-year period, differences in systolic and diastolic blood pressure between tight and loose blood control groups largely disappeared, as did benefits of tight control.
Citation
Barry, Henry, et al., editors. "Continued BP Control Important in T2DM (UKPDS)." EE+ POEM Archive, John Wiley & Sons, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/infoPOEMs/426348/all/Continued_BP_control_important_in_T2DM__UKPDS_.
Continued BP control important in T2DM (UKPDS). In: Barry HH, Ebell MHM, Shaughnessy AFA, et al, eds. EE+ POEM Archive. John Wiley & Sons; 2019. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426348/all/Continued_BP_control_important_in_T2DM__UKPDS_. Accessed October 3, 2024.
Continued BP control important in T2DM (UKPDS). (2019). In Barry, H., Ebell, M. H., Shaughnessy, A. F., & Slawson, D. C. (Eds.), EE+ POEM Archive. John Wiley & Sons. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426348/all/Continued_BP_control_important_in_T2DM__UKPDS_
Continued BP Control Important in T2DM (UKPDS) [Internet]. In: Barry HH, Ebell MHM, Shaughnessy AFA, Slawson DCD, editors. EE+ POEM Archive. John Wiley & Sons; 2019. [cited 2024 October 03]. Available from: https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426348/all/Continued_BP_control_important_in_T2DM__UKPDS_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Continued BP control important in T2DM (UKPDS)
ID - 426348
ED - Barry,Henry,
ED - Ebell,Mark H,
ED - Shaughnessy,Allen F,
ED - Slawson,David C,
BT - EE+ POEM Archive
UR - https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426348/all/Continued_BP_control_important_in_T2DM__UKPDS_
PB - John Wiley & Sons
DB - Evidence Central
DP - Unbound Medicine
ER -