Continued BP control important in T2DM (UKPDS)
Clinical QuestionIs the benefit of blood pressure control in type 2 diabetes mellitus sustained after 10 years?
Bottom LineGood control of blood pressure (defined as < 150/85 in this study) in patients with diabetes is critical, and this study reinforces the importance of maintaining good blood pressure control over time. (LOE = 2b)
ReferenceHolman RR, Paul SK, Bethel MA, Neil HA, Matthews DR. Long-term follow-up after tight control of blood pressure in type 2 diabetes. N Engl J Med 2008;359(15):1565-1576. [PMID:18784091]
Study DesignCohort (prospective)
SynopsisThis is a follow-up to the landmark United Kingdom Prospective Diabetes Study trial. Initially, 1148 patients with newly diagnosed type 2 diabetes mellitus and hypertension were randomized in a 2-to-1 ratio to tight blood pressure control with captopril or atenolol (target blood pressure of < 150/85 mm Hg) or less tight control without either drug (< 180/105 mm Hg). The mean age of patients was 56 years and 87% were white. The study found important reductions in any diabetes-related end point (including death), stroke, and microvascular disease among patients randomized to the tight control group over the 8-year mean follow-up period. At the end of the study, patients who had not died, emigrated, or dropped out (n = 884) were followed up for another 10 years. At the end of the 10-year period, 372 patients had completed post-trial monitoring. Over the 10-year period, differences in systolic and diastolic blood pressure between tight and loose blood control groups largely disappeared, as did benefits of tight control.
Barry, Henry, et al., editors. "Continued BP Control Important in T2DM (UKPDS)." EE+ POEM Archive, John Wiley & Sons, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/infoPOEMs/426348/all/Continued_BP_control_important_in_T2DM__UKPDS_.
Continued BP control important in T2DM (UKPDS). In: Barry HH, Ebell MHM, Shaughnessy AFA, et al, eds. EE+ POEM Archive. John Wiley & Sons; 2019. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426348/all/Continued_BP_control_important_in_T2DM__UKPDS_. Accessed June 7, 2023.
Continued BP control important in T2DM (UKPDS). (2019). In Barry, H., Ebell, M. H., Shaughnessy, A. F., & Slawson, D. C. (Eds.), EE+ POEM Archive. John Wiley & Sons. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426348/all/Continued_BP_control_important_in_T2DM__UKPDS_
Continued BP Control Important in T2DM (UKPDS) [Internet]. In: Barry HH, Ebell MHM, Shaughnessy AFA, Slawson DCD, editors. EE+ POEM Archive. John Wiley & Sons; 2019. [cited 2023 June 07]. Available from: https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426348/all/Continued_BP_control_important_in_T2DM__UKPDS_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Continued BP control important in T2DM (UKPDS) ID - 426348 ED - Barry,Henry, ED - Ebell,Mark H, ED - Shaughnessy,Allen F, ED - Slawson,David C, BT - EE+ POEM Archive UR - https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426348/all/Continued_BP_control_important_in_T2DM__UKPDS_ PB - John Wiley & Sons DB - Evidence Central DP - Unbound Medicine ER -