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Moderate coffee consumption safe after AMI


Clinical Question:
Is coffee consumption safe after acute myocardial infarction?

Bottom Line:
Coffee consumption does not increase the risk of cardiovascular events following acute myocardial infarction (AMI). (LOE = 1b)

Silletta MG, Marfisi R, Levantesi G, et al, for the GISSI-Prevenzione Investigators. Coffee consumption and risk of cardiovascular events after acute myocardial infarction. Circulation 2007;116(25):2944-2951.  [PMID:18056527]

Study Design:
Cohort (prospective)

Outpatient (any)

The data on coffee consumption are somewhat conflicting. These authors used data from the Italian GISSI-Prevenzione trial, a randomized trial of vitamin E and omega-3 fatty acids in 11,323 adults with recent acute myocardial infarction (AMI). Follow-up was excellent (more than 99%). Coffee consumption was ascertained at baseline and again at 6 months, 18 months, and 42 months. Consumption was categorized as none, less than 2 cups, 2 to 4 cups, and more than 4 cups per day. Heavy coffee users were more likely to be male, obese, smokers, and young. There were also differences in comorbidities and medication use between heavy coffee users and others. In the unadjusted analysis, heavy coffee drinking was protective for the primary outcome of subsequent cardiovascular events (cardiovascular death, nonfatal AMI, or nonfatal stroke). In the analysis adjusted for age, sex, and smoking, that benefit persisted, but it was no longer significant. The relative risk of coffee consumption compared with no coffee was 1.02 (95% CI, 0.87-12) for less than 2 cups, 0.91 (0.75-1.09) for 2 to 4 cups, and 0.88 (0.64-1.2) for more than 4 cups.

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Slawson, David C., et al., editors. "Moderate Coffee Consumption Safe After AMI." EE+ POEM Archive, John Wiley & Sons, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/infoPOEMs/426270/all/Moderate_coffee_consumption_safe_after_AMI.
Moderate coffee consumption safe after AMI. In: Slawson DC, Shaughnessy AF, Ebell MH, et al, eds. EE+ POEM Archive. John Wiley & Sons; 2019. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426270/all/Moderate_coffee_consumption_safe_after_AMI. Accessed May 21, 2019.
Moderate coffee consumption safe after AMI. (2019). In Slawson, D. C., Shaughnessy, A. F., Ebell, M. H., & Barry, H. (Eds.), EE+ POEM Archive. Available from https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426270/all/Moderate_coffee_consumption_safe_after_AMI
Moderate Coffee Consumption Safe After AMI [Internet]. In: Slawson DC, Shaughnessy AF, Ebell MH, Barry H, editors. EE+ POEM Archive. John Wiley & Sons; 2019. [cited 2019 May 21]. Available from: https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426270/all/Moderate_coffee_consumption_safe_after_AMI.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Moderate coffee consumption safe after AMI ID - 426270 ED - Slawson,David C, ED - Shaughnessy,Allen F, ED - Ebell,Mark H, ED - Barry,Henry, BT - EE+ POEM Archive UR - https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426270/all/Moderate_coffee_consumption_safe_after_AMI PB - John Wiley & Sons DB - Evidence Central DP - Unbound Medicine ER -