Omega-3 fatty acids have small analgesic effect
Clinical Question
Can long-term dosing of omega-3 fatty acids decrease inflammatory joint pain?
Bottom Line
In patients with joint pain due to rheumatoid arthritis, inflammatory bowel disease, or dysmenorrhea, continuous therapy with fish oil or other sources of omega-3 fatty acids produced statistically significant decreases in pain. The onset of action is approximately 3 months. Even though the benefit may be small, the lack of significant side effects and the beneficial effect on cardiovascular disease (Circulation 2002;106:2747-2757) make fish oil and other sources a useful option in patients with pain due to inflammation. (LOE = 1a)
Reference
Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain 2007;129;210-223. [PMID:17335973]
Study Design
Meta-analysis (randomized controlled trials)
Funding
Self-funded or unfunded
Setting
Various (meta-analysis)
Synopsis
Omega-3 fatty acids may decrease inflammation by competing with arachidonic acid, the precursor to the inflammatory prostaglandins. To identify research for inclusion, the researchers searched several databases for English-language randomized clinical trials, also searching references of retrieved articles for additional relevant studies. The data were abstracted by a single person but 2 researchers independently assessed study quality. The resulting meta-analysis included 17 studies enrolling a total of 823 patients, though not all studies evaluated all outcomes. The studies used fish, seal, or flaxseed oil to provide various amounts of omega-3 fatty acid. High dose was defined as greater than 2.7 g daily. All comparisons were against inactive placebo or olive oil, which might have antiinflammatory property. Daily supplementation for 3 to 4 months reduced patient-reported joint pain intensity, minutes of morning stiffness, number of painful joints, and analgesic consumption. The benefit was not striking and was not found in physician-reported scores or the Ritchie articular index. The quality of included studies was satisfactory.
Citation
Barry, Henry, et al., editors. "Omega-3 Fatty Acids Have Small Analgesic Effect." EE+ POEM Archive, John Wiley & Sons, 2024. Evidence Central, evidence.unboundmedicine.com/evidence/view/infoPOEMs/426106/all/Omega_3_fatty_acids_have_small_analgesic_effect.
Omega-3 fatty acids have small analgesic effect. In: Barry HH, Ebell MHM, Shaughnessy AFA, et al, eds. EE+ POEM Archive. John Wiley & Sons; 2024. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426106/all/Omega_3_fatty_acids_have_small_analgesic_effect. Accessed December 13, 2024.
Omega-3 fatty acids have small analgesic effect. (2024). In Barry, H., Ebell, M. H., Shaughnessy, A. F., & Slawson, D. C. (Eds.), EE+ POEM Archive. John Wiley & Sons. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426106/all/Omega_3_fatty_acids_have_small_analgesic_effect
Omega-3 Fatty Acids Have Small Analgesic Effect [Internet]. In: Barry HH, Ebell MHM, Shaughnessy AFA, Slawson DCD, editors. EE+ POEM Archive. John Wiley & Sons; 2024. [cited 2024 December 13]. Available from: https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426106/all/Omega_3_fatty_acids_have_small_analgesic_effect.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Omega-3 fatty acids have small analgesic effect
ID - 426106
ED - Barry,Henry,
ED - Ebell,Mark H,
ED - Shaughnessy,Allen F,
ED - Slawson,David C,
BT - EE+ POEM Archive
UR - https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426106/all/Omega_3_fatty_acids_have_small_analgesic_effect
PB - John Wiley & Sons
DB - Evidence Central
DP - Unbound Medicine
ER -