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Adrenaline (epinephrine) auto-injector for the treatment of anaphylaxis with and without cardiovascular collapse in the community

Evidence Summaries

Level of Evidence = A

Adrenaline auto-injector is effective and shortens the delay for treatment for anaphylaxis although there is no evidence from randomized controlled trials.

There are no randomized controlled trials 1 of adrenaline auto-injectors in the treatment of anaphylaxis. While adrenaline is the drug of choice for anaphylaxis, trials are unlikely to be performed because of ethical concerns associated with randomization to placebo. Several observational studies and case series show a better prognosis for patients who receive adrenaline early compared to those who receive delayed adrenaline.

References

1. Sheikh A, Simons FE, Barbour V et al. Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community. Cochrane Database Syst Rev 2012;8:CD008935.  [PMID:22895980]


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Adrenaline (epinephrine) auto-injector for the treatment of anaphylaxis with and without cardiovascular collapse in the community is a sample topic from the Evidence-Based Medicine Guidelines.

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Citation

"Adrenaline (epinephrine) Auto-injector for the Treatment of Anaphylaxis With and Without Cardiovascular Collapse in the Community." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/457666/all/Adrenaline__epinephrine__auto_injector_for_the_treatment_of_anaphylaxis_with_and_without_cardiovascular_collapse_in_the_community.
Adrenaline (epinephrine) auto-injector for the treatment of anaphylaxis with and without cardiovascular collapse in the community. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/457666/all/Adrenaline__epinephrine__auto_injector_for_the_treatment_of_anaphylaxis_with_and_without_cardiovascular_collapse_in_the_community. Accessed March 24, 2019.
Adrenaline (epinephrine) auto-injector for the treatment of anaphylaxis with and without cardiovascular collapse in the community. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/457666/all/Adrenaline__epinephrine__auto_injector_for_the_treatment_of_anaphylaxis_with_and_without_cardiovascular_collapse_in_the_community
Adrenaline (epinephrine) Auto-injector for the Treatment of Anaphylaxis With and Without Cardiovascular Collapse in the Community [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 March 24]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/457666/all/Adrenaline__epinephrine__auto_injector_for_the_treatment_of_anaphylaxis_with_and_without_cardiovascular_collapse_in_the_community.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Adrenaline (epinephrine) auto-injector for the treatment of anaphylaxis with and without cardiovascular collapse in the community ID - 457666 BT - Evidence-Based Medicine Guidelines UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/457666/all/Adrenaline__epinephrine__auto_injector_for_the_treatment_of_anaphylaxis_with_and_without_cardiovascular_collapse_in_the_community PB - Duodecim Medical Publications Limited DB - Evidence Central DP - Unbound Medicine ER -