Level of Evidence = B
An abnormal screening glucose tolerance test in pregnancy appears to increase the future risk of diabetes.
Comment: The quality of evidence is upgraded by large magnitude of effect.
In a population-based, retrospective cohort study 1 15,381 women referred for an antepartum oral glucose tolerance test (OGTT) indicative of an abnormal 50-g glucose challenge test (GCT), but without GDM, were matched (for age, region, socioeconomic status, and year of delivery) with up to 4 other women without such referral (n = 61,237). The two cohorts were followed over a median 6.4 years for the development of diabetes. The rate of incident DM was 5.04 cases per 1000 person-years in the cohort of women who underwent an antepartum OGTT, compared with 1.74 cases per 1000 person-years in women without an OGTT. The hazard ratio for subsequent DM in women with abnormal GCT was 2.56 (95% CI 2.28 to 2.87, P < 0.0001).
1. Retnakaran R, Shah BR. Abnormal screening glucose challenge test in pregnancy and future risk of diabetes in young women. Diabet Med 2009;26(5):474-7. [PMID:19646185]
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"Abnormal Screening Glucose Challenge Test in Pregnancy and Future Risk of Diabetes." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/457645/all/Abnormal_screening_glucose_challenge_test_in_pregnancy_and_future_risk_of_diabetes.
Abnormal screening glucose challenge test in pregnancy and future risk of diabetes. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/457645/all/Abnormal_screening_glucose_challenge_test_in_pregnancy_and_future_risk_of_diabetes. Accessed August 25, 2019.
Abnormal screening glucose challenge test in pregnancy and future risk of diabetes. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/457645/all/Abnormal_screening_glucose_challenge_test_in_pregnancy_and_future_risk_of_diabetes
Abnormal Screening Glucose Challenge Test in Pregnancy and Future Risk of Diabetes [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 August 25]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/457645/all/Abnormal_screening_glucose_challenge_test_in_pregnancy_and_future_risk_of_diabetes.
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