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Adalimumab for treating rheumatoid arthritis

Evidence Summaries

Level of Evidence = A

Adalimumab 40 mg every other week plus methotrexate decreases pain and swelling and slows down joint damage in rheumatoid arthritis.

A Cochrane review 1 on the human anti-TNFalpha monoclonal antibody adalimumab in the treatment of rheumatoid arthritis (RA) included six studies with a total of 2381 subjects. With adalimumab 40 mg s.c. every other week + methotrexate (or DMARDs, disease-modifying anti-rheumatic drugs), the RRs to achieve an American College of Rheumatology (ACR) criteria response 20, 50, and 70 at 52 weeks as compared to placebo were 2.46 (95%CI 1.87 to 3.22), 4.37 (95% CI 2.77 to 6.91), and 5.15 (95% CI 2.60 to 10.22), with NNTs of 2.9, 3.1, and 5.3, respectively. At 52 weeks, adalimumab 40 mg e.o.w. and 20 mg every week (e.w.) significantly slowed the radiological progression, erosion score, and joint space score (only with 40 mg e.o.w.). Adalimumab in monotherapy is also efficacious but the effect size is lower than with combined therapy. With adalimumab 40 mg s.c. every other week as monotherapy versus placebo, the RRs to achieve an ACR 20, 50, and 70 response at 24/26 weeks were 1.91 (95% CI 1.17 to 3.10), 2.84 (95% CI 1.58 to 5.12), and 7.33 (95% CI 2.25 to 33.90) with NNTs of 5.0 (95% CI 3.0 to 9.0), 7.0 (95% CI 4.0 to 20.0), and 9.0 (95% CI 3.0 to 38.0), respectively.

In most of the analysed studies and comparisons, there were not significant differences in safety outcomes between adalimumab and control groups.

References

1. Navarro-Sarabia F, Ariza-Ariza R, Hernandez-Cruz B, Villanueva I. Adalimumab for treating rheumatoid arthritis. Cochrane Database Syst Rev 2005 Jul 20;(3):CD005113.  [PMID:16034967]


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Citation

"Adalimumab for Treating Rheumatoid Arthritis." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/456555/all/Adalimumab_for_treating_rheumatoid_arthritis.
Adalimumab for treating rheumatoid arthritis. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/456555/all/Adalimumab_for_treating_rheumatoid_arthritis. Accessed August 21, 2019.
Adalimumab for treating rheumatoid arthritis. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/456555/all/Adalimumab_for_treating_rheumatoid_arthritis
Adalimumab for Treating Rheumatoid Arthritis [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 August 21]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/456555/all/Adalimumab_for_treating_rheumatoid_arthritis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Adalimumab for treating rheumatoid arthritis ID - 456555 BT - Evidence-Based Medicine Guidelines UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/456555/all/Adalimumab_for_treating_rheumatoid_arthritis PB - Duodecim Medical Publications Limited DB - Evidence Central DP - Unbound Medicine ER -