Altered dietary salt in pre-eclampsia

Evidence Summaries

Level of Evidence = C
Reduced salt intake may be effective for beneficial outcomes in pregnant women with pre-eclampsia.

A trial 1 included 200 women: 50 control women with healthy pregnancy, 150 women with pre-eclampsia (PE). Daily salt and potassium intake was estimated based on calculation of 24-hour urinary sodium U[Na+] and potassium U[K+] excretion. At the end of the measurements, the pregnant women with PE were divided into tertiles according to U[Na+]/[K+]: low Na/K group (n=50, mean U[Na+]/[K+]: 1,04±0,32), medium Na/K group (n=50, mean U[Na+]/[K+]: 2,49± 0,54), high Na/K group (n=50, mean U[Na+]/[K+]: 6,62±3,41). The mean systolic and diastolic blood pressure levels were significantly lower in low Na/K group compared with medium or high Na/K groups (p=0.024, p=0.0002; respectively). Serum creatinine was significantly lower in low Na/K group than high Na/K group (p=0.025). Frequency of severe pre-eclampsia is lower in low Na/K group than medium or high Na/K groups (p=0.002, p=0.0001; respectively). Birth weight and gestational age at birth were higher in low Na/K group compared with high Na/K group (p=0.045, p=0.0002; respectively). After adjusting for covariates, blood pressure and creatinine levels were independently associated with 24 hours urinary [Na+]/[K+].


1. Yilmaz ZV, Akkas E, Türkmen GG et al. Dietary sodium and potassium intake were associated with hypertension, kidney damage and adverse perinatal outcome in pregnant women with preeclampsia. Hypertens Pregnancy 2017;36(1):77-83.  [PMID:27835032]

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