There is no direct evidence that aciclovir has a beneficial effect on outcomes in Ramsay Hunt syndrome (herpes zoster oticus, HZO, associated with acute facial paralysis), although the use of aciclovir in patients with HZ in other parts of the body suggest that they have a role also in HZO.
A Cochrane review 1 included 1 low-quality study with a total of 15 subjects. All participants received intravenous corticosteroids (methylprednisolone 20 mg/8 hours for 10 days). Seven participants only received this treatment (control group) whilst eight (the treatment group) received in addition intravenous acyclovir (10 mg/kg/8h for 10 days). No statistically significant difference between the two groups was found.
Comment: The quality of evidence is downgraded by imprecise results (very few patients and wide confidence intervals) and by study quality (lack of blinding).
1. Uscategui T, Dorée C, Chamberlain IJ, Burton MJ. Antiviral therapy for Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults. Cochrane Database Syst Rev 2008 Oct 8;(4):CD006851. [PMID:18843734]
Copyright © 2020 Duodecim Medical Publications Limited.
Aciclovir for Ramsay Hunt syndrome
is a sample topic from the Evidence-Based Medicine Guidelines
To view other topics, please sign in or purchase a subscription.
Evidence Central is an integrated web and mobile solution that helps clinicians quickly answer etiology, diagnosis, treatment, and prognosis questions using the latest evidence-based research. Complete Product Information.
"Aciclovir for Ramsay Hunt Syndrome." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/455861/all/Aciclovir_for_Ramsay_Hunt_syndrome.
Aciclovir for Ramsay Hunt syndrome. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/455861/all/Aciclovir_for_Ramsay_Hunt_syndrome. Accessed June 7, 2020.
Aciclovir for Ramsay Hunt syndrome. (2019). In Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited. Retrieved June 07, 2020, from https://evidence.unboundmedicine.com/evidence/view/EBMG/455861/all/Aciclovir_for_Ramsay_Hunt_syndrome
Aciclovir for Ramsay Hunt Syndrome [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2020 June 07]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/455861/all/Aciclovir_for_Ramsay_Hunt_syndrome.
TY - ELEC
T1 - Aciclovir for Ramsay Hunt syndrome
ID - 455861
BT - Evidence-Based Medicine Guidelines
UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/455861/all/Aciclovir_for_Ramsay_Hunt_syndrome
PB - Duodecim Medical Publications Limited
DB - Evidence Central
DP - Unbound Medicine