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Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas

Evidence Summaries

Level of Evidence = A

In patients with anaplastic oligodendrogliomas and oligoastrocytomas, early adjuvant chemotherapy in addition to standard treatment of surgery and radiotherapy improves progression-free survival almost a year at a cost of significant toxicity, but it appears not to improve overall survival.

A Cochrane review 1 included 2 studies with a total of 657 subjects. The patients were aged 16 to 70 years and they were followed for a median of 5 years.The studies tested surgery plus radiotherapy (RT) plus early procarbazine, lomustine, and vincristine (PCV) chemotherapy versus surgery plus RT alone. There were differences between the studies in the definition of an anaplastic tumor and treatment and dose of PCV, which prevented pooling. Both trials showed a small non-statistically significant benefit in favor of early PCV plus RT treatment; the other 4.7 years vs. 4.9 years (HR = 0.90; 95% CI 0.66 to 1.24; P = 0.26) and the other 2.6 years vs. 3.4 years (HR = 0.85; 95% CI 0.65 to 1.1; P = 0.23). However, both studies found a statistically significant increase in progression-free survival (PFS) associated with the administration of PCV chemotherapy before surgery or after surgery and RT, with the benefit ranging from 10 months (HR = 0.68; 95% CI 0.53 to 0.87) to 11 months (HR = 0.69; 95% CI 0.52 to 0.91). Patients on the combined modality arms of each study experienced significant toxicity. Co-deletion of chromosomes 1p and 19q identifies a favorable subgroup of tumors with better overall survival outcomes. The predictive value of 1p and 19q co-deletions is less clear with one study observing a longer PFS with chemotherapy, while the other study did not.

References

1. Quon H, Abdulkarim B. Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas. Cochrane Database Syst Rev 2008 Apr 16;(2):CD007104.  [PMID:18425979]


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Citation

"Adjuvant Treatment of Anaplastic Oligodendrogliomas and Oligoastrocytomas." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/455704/all/_________Adjuvant_treatment_of_anaplastic_oligodendrogliomas_and_oligoastrocytomas______.
Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/455704/all/_________Adjuvant_treatment_of_anaplastic_oligodendrogliomas_and_oligoastrocytomas______. Accessed August 19, 2019.
Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/455704/all/_________Adjuvant_treatment_of_anaplastic_oligodendrogliomas_and_oligoastrocytomas______
Adjuvant Treatment of Anaplastic Oligodendrogliomas and Oligoastrocytomas [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 August 19]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/455704/all/_________Adjuvant_treatment_of_anaplastic_oligodendrogliomas_and_oligoastrocytomas______.
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TY - ELEC T1 - Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas ID - 455704 BT - Evidence-Based Medicine Guidelines UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/455704/all/_________Adjuvant_treatment_of_anaplastic_oligodendrogliomas_and_oligoastrocytomas______ PB - Duodecim Medical Publications Limited DB - Evidence Central DP - Unbound Medicine ER -