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Abatacept for rheumatoid arthritis

Evidence Summaries

Level of Evidence = B

Abatacept appears to be effective in the treatment of moderate to severe rheumatoid arthritis.

A Cochrane review 1 included 7 studies with a total of 2908 subjects. Compared with placebo, abatacept increased the achievement of an ACR 50 response (a 50% improvement in tender and swollen joint counts and the same level of improvement in 3 of the 5 following variables: patient and physician global assessments, pain, HAQ (Health Assessment Questionnaire), and acute phase reactants) at one year (RR 2.21, 95% CI 1.73 to 2.82; NNT 5, 95% CI 4 to 7; 3 studies, n=993). Significant improvements in physical function (RR 1.62, 95% CI 1.35 to 1.95; 1 study, n=638) and a reduction in disease activity (RR 4.33, 95% CI 2.84 to 6.59; 1 study, n=638) and pain were found in abatacept-treated patients compared to placebo. Abatacept significantly slowed the radiographic progression of joint damage at 12 months compared to placebo (MD -0.27, 95% CI -0.42 to -0.12; 1 study, n=586), although it is not clear what the clinical relevance of this difference is. Total adverse events were greater in the abatacept group (RR 1.05, 95% CI 1.01 to 1.08; 5 studies, n=2871). Other harm outcomes were not significant with the exception of a greater number of serious infections at 12 months in the abatacept group (Peto OR 1.91, 95% CI 1.07 to 3.42; 3 studies, n=2214). Serious adverse events were increased when abatacept was given in combination with other biologics (RR 2.30, 95% CI 1.15 to 4.62; 2 studies, n=288).

Comment: The quality of evidence is downgraded by study quality (more than 20% loss to follow up and inadequate intention-to-treat adherence).

References

1. Maxwell L, Singh JA. Abatacept for rheumatoid arthritis. Cochrane Database Syst Rev 2009;(4):CD007277.  [PMID:19821401]


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Citation

"Abatacept for Rheumatoid Arthritis." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/455498/all/Abatacept_for_rheumatoid_arthritis.
Abatacept for rheumatoid arthritis. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/455498/all/Abatacept_for_rheumatoid_arthritis. Accessed August 21, 2019.
Abatacept for rheumatoid arthritis. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/455498/all/Abatacept_for_rheumatoid_arthritis
Abatacept for Rheumatoid Arthritis [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 August 21]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/455498/all/Abatacept_for_rheumatoid_arthritis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Abatacept for rheumatoid arthritis ID - 455498 BT - Evidence-Based Medicine Guidelines UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/455498/all/Abatacept_for_rheumatoid_arthritis PB - Duodecim Medical Publications Limited DB - Evidence Central DP - Unbound Medicine ER -