A patient with drug addiction in primary care – Related resources

Cochrane reviews

  • Buprenorphine is more effective than clonidine or lofexidine and of similar effectiveness to methadone for the management of opioid withdrawal [Evidence Level: A].
  • Carbamazepine seems to have no effect for cocaine dependence, although there is no evidence from controlled trials [Evidence Level: C].
  • The use of antidepressants for cocaine abuse appears not to be beneficial [Evidence Level: B].
  • Dopamine antagonists appear not to be effective for cocaine dependence [Evidence Level: B].
  • There seems to be no significantly beneficial drug for the treatment of amphetamine dependence and withdrawal, although the evidence is insufficient. [Evidence Level: C].
  • Contracts may have some potential in improving adherence to treatment, prevention and health promotion activities [Evidence Level: C].

Other evidence summaries

  • Family-couples therapy is superior to non-family modalities in the treatment of drug abuse
  • Educating young people may have only a very modest effect on drug using behaviour. Motivational interviewing and some family interventions may have some benefit [Evidence Level: B].


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