Adjuvant chemotherapy increases disease-free survival although no overall survival in patients with stage II colon cancer.
A Cochrane review 1 included 33 randomized trials and 17 meta-analyses containing data on stage II colon cancer patients undergoing adjuvant therapy versus surgery alone. The participants in the trials were patients with completely resected colon (n=7,731) or rectal (n=7,600) cancers. With regards to the effect of adjuvant therapy on stage II colon cancer, the pooled relative risk ratio for overall survival was 0.96 (95% CL 0.88 to 1.05). With regards to disease-free survival, the pooled relative risk ratio was 0.83 (95% Cl 0.75 to 0.92).
1. Figueredo A, Coombes ME, Mukherjee S. Adjuvant therapy for completely resected stage II colon cancer. Cochrane Database Syst Rev 2008;(3):CD005390. [PMID:18646127]
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"Adjuvant Chemotherapy in Colorectal Cancer." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/454545/all/Adjuvant_chemotherapy_in_colorectal_cancer.
Adjuvant chemotherapy in colorectal cancer. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/454545/all/Adjuvant_chemotherapy_in_colorectal_cancer. Accessed April 17, 2021.
Adjuvant chemotherapy in colorectal cancer. (2019). In Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited. https://evidence.unboundmedicine.com/evidence/view/EBMG/454545/all/Adjuvant_chemotherapy_in_colorectal_cancer
Adjuvant Chemotherapy in Colorectal Cancer [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2021 April 17]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/454545/all/Adjuvant_chemotherapy_in_colorectal_cancer.
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