Alpha-blockers for chronic abacterial prostatitis

Evidence Summaries

Level of Evidence = B

Alpha-blockers alone or combined with antibiotics appear to be effective in improving symptoms in men with chronic abacterial prostatitis.

In a meta-analysis of 23 studies ¹, α-blockers compared with placebo were associated with significant improvement in symptoms with standardized mean differences of total symptom -1.7 (95% CI, -2.8 to -0.6), pain -1.1 (95% CI -1.8 to -0.3), voiding -1.4 (95% CI -2.3 to -0.5) and quality-of-life scores -1.0 (95% CI -1.8 to -0.2). Patients receiving α-blockers or anti-inflammatory medications had a higher chance of favorable response compared with placebo, with pooled RRs of 1.6 (95% CI 1.1-2.3) and 1.8 (95% CI 1.2-2.6), respectively. Contour-enhanced funnel plots suggested the presence of publication bias for smaller studies of α-blocker therapies.

The network meta-analysis suggested benefits of antibiotics in decreasing total symptom scores (-9.8; 95% CI -15.1 to -4.6), pain scores (-4.4; 95% CI -7.0 to -1.9), voiding scores (-2.8; 95% CI -4.1 to -1.6), and quality-of-life scores (-1.9; 95% CI -3.6 to -0.2) compared with placebo. Combining α-blockers and antibiotics yielded the greatest benefits compared with placebo, with corresponding decreases of -13.8 (95% CI -17.5 to -10.2) for total symptom scores, -5.7 (95% CI -7.8 to -3.6) for pain scores, -3.7 (95% CI -5.2 to -2.1) for voiding, and -2.8 (95% Cl -4.7 to -0.9) for quality-of-life scores.

Comment: The level of evidence is downgraded by potential reporting bias.

References

1. Anothaisintawee T, Attia J, Nickel JC, Thammakraisorn S, Numthavaj P, McEvoy M, Thakkinstian A. Management of chronic prostatitis/chronic pelvic pain syndrome: a systematic review and network meta-analysis. JAMA 2011 Jan 5;305(1):78-86. [PMID:21205969].

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Citation

"Alpha-blockers for Chronic Abacterial Prostatitis." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/454147/all/Alpha_blockers_for_chronic_abacterial_prostatitis.

Alpha-blockers for chronic abacterial prostatitis. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/454147/all/Alpha_blockers_for_chronic_abacterial_prostatitis. Accessed January 19, 2019.

Alpha-blockers for chronic abacterial prostatitis. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/454147/all/Alpha_blockers_for_chronic_abacterial_prostatitis

Alpha-blockers for Chronic Abacterial Prostatitis [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 January 19]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/454147/all/Alpha_blockers_for_chronic_abacterial_prostatitis

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TY - ELEC T1 - Alpha-blockers for chronic abacterial prostatitis ID - 454147 BT - Evidence-Based Medicine Guidelines UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/454147/all/Alpha_blockers_for_chronic_abacterial_prostatitis PB - Duodecim Medical Publications Limited DB - Evidence Central DP - Unbound Medicine ER -