The effect of alcohol use and elevated blood pressure on the risk of cerebral haemorrhage may be synergistic.
A population of 1621 individuals over 40 years of age were monitored for 26 years starting in 1961 1 . In the group with elevated blood pressure, the age-and-sex-controlled risk of cerebral haemorrhage was significantly increased (relative risk 3.13, 95% confidence interval 1.08 - 9.10) compared to the non-drinkers. In those with normal blood pressure, the use of alcohol did not increase the risk of cerebral haemorrhage. In case-control studies the crude OR for high alcohol intake was 3.36 (95% CI, 2.21 to 5.12) and for hypertension 3.68 (95% CI, 2.52 to 5.38) 2 .
1. Kiyohara Y, Kato I, Iwamoto H, Nakayama K, Fujishima M. The impact of alcohol and hypertension on stroke incidence in a general Japanese population. The Hisayama Study. Stroke 1995 Mar;26(3):368-72. [PMID:7886708]
2. Ariesen MJ, Claus SP, Rinkel GJ, Algra A. Risk factors for intracerebral hemorrhage in the general population: a systematic review. Stroke 2003 Aug;34(8):2060-5. [PMID:12843354]
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"Alcohol as a Risk Factor in Cerebral Haemorrhage." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/453978/all/Alcohol_as_a_risk_factor_in_cerebral_haemorrhage.
Alcohol as a risk factor in cerebral haemorrhage. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/453978/all/Alcohol_as_a_risk_factor_in_cerebral_haemorrhage. Accessed December 15, 2019.
Alcohol as a risk factor in cerebral haemorrhage. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/453978/all/Alcohol_as_a_risk_factor_in_cerebral_haemorrhage
Alcohol as a Risk Factor in Cerebral Haemorrhage [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 December 15]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/453978/all/Alcohol_as_a_risk_factor_in_cerebral_haemorrhage.
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