Adjunctive therapies for AIDS dementia complex
Evidence Summaries
Evidence Summaries
Level of Evidence = B
A Cochrane review 1 included 10 studies with a total of 711 subjects. All the studies were phase 2 trials. The trials were heterogeneous in terms of types, dosages, routes and frequencies of administration of the adjunctive therapies. Adjunctive drugs included in the studies were peptide T, selegiline (deprenyl), CPI-1189, OPC-14117, valproic acid, thioctic acid, nimodipine, memantine and lexipafant. There were no significant differences between the treated and placebo groups on neuropsychological test scores, number of those that complete the assign dosage of experimental medication, adverse effects, and all-cause mortality, though the adjunctive drugs were well tolerated and safe.
Comment: The quality of evidence is downgraded by inconsistency (heterogeneity in interventions and outcomes).
References
References
1. Uthman OA, Abdulmalik JO. Adjunctive therapies for AIDS dementia complex. Cochrane Database Syst Rev. 2008;(3):CD006496.
Copyright © 2019 Duodecim Medical Publications Limited.
Adjunctive therapies for AIDS dementia complex is a sample topic from the Evidence-Based Medicine Guidelines.
To view other topics, please sign in or purchase a subscription.
Evidence Central is an integrated web and mobile solution that helps clinicians quickly answer etiology, diagnosis, treatment, and prognosis questions using the latest evidence-based research. Complete Product Information.
Citation
"Adjunctive Therapies for AIDS Dementia Complex." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/453283/all/Adjunctive_therapies_for_AIDS_dementia_complex.
Adjunctive therapies for AIDS dementia complex. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/453283/all/Adjunctive_therapies_for_AIDS_dementia_complex. Accessed December 5, 2019.
Adjunctive therapies for AIDS dementia complex. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/453283/all/Adjunctive_therapies_for_AIDS_dementia_complex
Adjunctive Therapies for AIDS Dementia Complex [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 December 05]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/453283/all/Adjunctive_therapies_for_AIDS_dementia_complex.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Adjunctive therapies for AIDS dementia complex
ID - 453283
BT - Evidence-Based Medicine Guidelines
UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/453283/all/Adjunctive_therapies_for_AIDS_dementia_complex
PB - Duodecim Medical Publications Limited
DB - Evidence Central
DP - Unbound Medicine
ER -