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Adjunctive therapies for AIDS dementia complex

Evidence Summaries

Level of Evidence = B

Adjunctive therapies appear not to improve improves cognitive performance or quality of life for patients with AIDS dementia complex (ADC).

A Cochrane review ¹ included 10 studies with a total of 711 subjects. All the studies were phase 2 trials. The trials were heterogeneous in terms of types, dosages, routes and frequencies of administration of the adjunctive therapies. Adjunctive drugs included in the studies were peptide T, selegiline (deprenyl), CPI-1189, OPC-14117, valproic acid, thioctic acid, nimodipine, memantine and lexipafant. There were no significant differences between the treated and placebo groups on neuropsychological test scores, number of those that complete the assign dosage of experimental medication, adverse effects, and all-cause mortality, though the adjunctive drugs were well tolerated and safe.

Comment: The quality of evidence is downgraded by inconsistency (heterogeneity in interventions and outcomes).

References

1. Uthman OA, Abdulmalik JO. Adjunctive therapies for AIDS dementia complex. Cochrane Database Syst Rev. 2008;(3):CD006496.

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Citation

"Adjunctive Therapies for AIDS Dementia Complex." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/453283/all/Adjunctive_therapies_for_AIDS_dementia_complex.

Adjunctive therapies for AIDS dementia complex. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/453283/all/Adjunctive_therapies_for_AIDS_dementia_complex. Accessed February 17, 2019.

Adjunctive therapies for AIDS dementia complex. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/453283/all/Adjunctive_therapies_for_AIDS_dementia_complex

Adjunctive Therapies for AIDS Dementia Complex [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 February 17]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/453283/all/Adjunctive_therapies_for_AIDS_dementia_complex

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TY - ELEC T1 - Adjunctive therapies for AIDS dementia complex ID - 453283 BT - Evidence-Based Medicine Guidelines UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/453283/all/Adjunctive_therapies_for_AIDS_dementia_complex PB - Duodecim Medical Publications Limited DB - Evidence Central DP - Unbound Medicine ER -