There is insufficient evidence on the efficacy of amantadine in reducing fatigue in people with MS.
A Cochrane review 1 included 5 studies (1 parallel arms, 4 crossover trials) with a total of 272 subjects. Quality of the studies was generally poor and all trials were open to bias. All studies reported small and inconsistent improvements in fatigue, whereas the clinical relevance of these findings and the impact on patient's functioning and health related quality of life remained undetermined. The number of participants reporting side effects during amantadine therapy ranged from 10% to 57%.
Comment: The quality of evidence is downgraded by imprecise results (limited study size for each comparison), by limitations in study quality and by inconsistency (variability in results across studies).
1. Pucci E, Branãs P, D'Amico R, Giuliani G, Solari A, Taus C. Amantadine for fatigue in multiple sclerosis. Cochrane Database Syst Rev 2007 Jan 24;(1):CD002818. [PMID:17253480]
Copyright © 2020 Duodecim Medical Publications Limited.
Amantadine for fatigue in multiple sclerosis
is a sample topic from the Evidence-Based Medicine Guidelines
To view other topics, please sign in or purchase a subscription.
Evidence Central is an integrated web and mobile solution that helps clinicians quickly answer etiology, diagnosis, treatment, and prognosis questions using the latest evidence-based research. Complete Product Information.
"Amantadine for Fatigue in Multiple Sclerosis." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/453058/all/Amantadine_for_fatigue_in_multiple_sclerosis.
Amantadine for fatigue in multiple sclerosis. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/453058/all/Amantadine_for_fatigue_in_multiple_sclerosis. Accessed November 30, 2020.
Amantadine for fatigue in multiple sclerosis. (2019). In Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited. Retrieved November 30, 2020, from https://evidence.unboundmedicine.com/evidence/view/EBMG/453058/all/Amantadine_for_fatigue_in_multiple_sclerosis
Amantadine for Fatigue in Multiple Sclerosis [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2020 November 30]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/453058/all/Amantadine_for_fatigue_in_multiple_sclerosis.
TY - ELEC
T1 - Amantadine for fatigue in multiple sclerosis
ID - 453058
BT - Evidence-Based Medicine Guidelines
UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/453058/all/Amantadine_for_fatigue_in_multiple_sclerosis
PB - Duodecim Medical Publications Limited
DB - Evidence Central
DP - Unbound Medicine