Adrenaline is effective for anaphylaxis although there is no evidence from randomized controlled trials.
The quality of evidence is upgraded by very large magnitude of effect.Use adrenaline as first line treatment for anaphylaxis.
There are no randomized controlled trials (Cochrane review 1 ) comparing adrenaline with no intervention, placebo or other adrenergic agonists in the treatment of anaphylaxis. Several observational studies and case series show a rapid and often dramatic effect of adrenaline, and a better prognosis for patients who receive adrenaline early compared to those who receive no or delayed adrenaline.
1. Sheikh A, Shehata YA, Brown SG, Simons FE. Adrenaline (epinephrine) for the treatment of anaphylaxis with and without shock. Cochrane Database Syst Rev 2008;(4):CD006312 [Review content assessed as up-to-date: 29 November 2010]. [PMID:18843712]
Copyright © 2020 Duodecim Medical Publications Limited.
Adrenaline (epinephrine) for the treatment of anaphylaxis with and without shock
is a sample topic from the Evidence-Based Medicine Guidelines
To view other topics, please sign in or purchase a subscription.
Evidence Central is an integrated web and mobile solution that helps clinicians quickly answer etiology, diagnosis, treatment, and prognosis questions using the latest evidence-based research. Complete Product Information.
"Adrenaline (epinephrine) for the Treatment of Anaphylaxis With and Without Shock." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/451796/all/Adrenaline__epinephrine__for_the_treatment_of_anaphylaxis_with_and_without_shock.
Adrenaline (epinephrine) for the treatment of anaphylaxis with and without shock. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/451796/all/Adrenaline__epinephrine__for_the_treatment_of_anaphylaxis_with_and_without_shock. Accessed November 30, 2020.
Adrenaline (epinephrine) for the treatment of anaphylaxis with and without shock. (2019). In Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited. Retrieved November 30, 2020, from https://evidence.unboundmedicine.com/evidence/view/EBMG/451796/all/Adrenaline__epinephrine__for_the_treatment_of_anaphylaxis_with_and_without_shock
Adrenaline (epinephrine) for the Treatment of Anaphylaxis With and Without Shock [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2020 November 30]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/451796/all/Adrenaline__epinephrine__for_the_treatment_of_anaphylaxis_with_and_without_shock.
TY - ELEC
T1 - Adrenaline (epinephrine) for the treatment of anaphylaxis with and without shock
ID - 451796
BT - Evidence-Based Medicine Guidelines
UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/451796/all/Adrenaline__epinephrine__for_the_treatment_of_anaphylaxis_with_and_without_shock
PB - Duodecim Medical Publications Limited
DB - Evidence Central
DP - Unbound Medicine