Alzheimer's disease – Related resources

Cochrane reviews

  • There is no evidence that clioquinol (PBT1) would provide any clinical benefit for patients with Alzheimer's disease [Evidence Level: D].
  • Atypical antipsychotics are beneficial in the treatment of aggression, agitation and psychosis in people with Alzheimer's disease, but the risks of adverse events may outweigh the benefits, particularly with long term treatment [Evidence Level: A]
  • Statins are probably not effective for the treatment of Alzheimer's disease [Evidence Level: B].

Other evidence summaries

  • High-dose B vitamin supplements do not slow cognitive decline in individuals with mild to moderate Alzheimer’s disease [Evidence Level: A].

Internet resources

Literature

Clinical practice reviews

  • Mayeux R. Clinical practice. Early Alzheimer's disease. N Engl J Med 2010 Jun 10;362(23):2194-201.  [PMID:20558370]
  • Raina P, Santaguida P, Ismaila A, Patterson C, Cowan D, Levine M, Booker L, Oremus M. Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med 2008 Mar 4;148(5):379-97  [PMID:18316756]


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