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Alzheimer's disease – Related resources

Cochrane reviews

  • Selegiline may not have clinically significant effects on cognitive performance, mood and behaviour in Alzheimer's disease [Evidence Level: C].
  • There is no evidence that clioquinol (PBT1) would provide any clinical benefit for patients with Alzheimer's disease [Evidence Level: D].
  • Atypical antipsychotics are beneficial in the treatment of aggression, agitation and psychosis in people with Alzheimer's disease, but the risks of adverse events may outweigh the benefits, particularly with long term treatment [Evidence Level: A]
  • Statins are probably not effective for the treatment of Alzheimer's disease [Evidence Level: B].
  • Propentofylline may benefit cognition, global function and activities of daily living of people with Alzheimer's disease and/or vascular dementia [Evidence Level: C].

Other evidence summaries

  • There is insufficient evidence on improved patient outcomes on brain single-photon enhanced computed tomography (SPECT) in differentiating Alzheimer's disease (AD) from other dementias [Evidence Level: D].
  • High-dose B vitamin supplements do not slow cognitive decline in individuals with mild to moderate Alzheimer’s disease [Evidence Level: A].

Internet resources

Literature

Clinical practice reviews

  • Mayeux R. Clinical practice. Early Alzheimer's disease. N Engl J Med 2010 Jun 10;362(23):2194-201.  [PMID:20558370]
  • Raina P, Santaguida P, Ismaila A, Patterson C, Cowan D, Levine M, Booker L, Oremus M. Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med 2008 Mar 4;148(5):379-97  [PMID:18316756]


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Citation

"Alzheimer's Disease – Related Resources." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/451181/all/Alzheimer's_disease_–_Related_resources.
Alzheimer's disease – Related resources. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/451181/all/Alzheimer's_disease_–_Related_resources. Accessed March 23, 2019.
Alzheimer's disease – Related resources. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/451181/all/Alzheimer's_disease_–_Related_resources
Alzheimer's Disease – Related Resources [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 March 23]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/451181/all/Alzheimer's_disease_–_Related_resources.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Alzheimer's disease – Related resources ID - 451181 BT - Evidence-Based Medicine Guidelines UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/451181/all/Alzheimer's_disease_–_Related_resources PB - Duodecim Medical Publications Limited DB - Evidence Central DP - Unbound Medicine ER -