Alzheimer's disease – Related resources

Cochrane reviews

  • Selegiline may not have clinically significant effects on cognitive performance, mood and behaviour in Alzheimer's disease C.
  • There is no evidence that clioquinol (PBT1) would provide any clinical benefit for patients with Alzheimer's disease D.
  • Atypical antipsychotics are beneficial in the treatment of aggression, agitation and psychosis in people with Alzheimer's disease, but the risks of adverse events may outweigh the benefits, particularly with long term treatment A
  • Statins are probably not effective for the treatment of Alzheimer's disease B.
  • Propentofylline may benefit cognition, global function and activities of daily living of people with Alzheimer's disease and/or vascular dementia C.

Other evidence summaries

  • There is insufficient evidence on improved patient outcomes on brain single-photon enhanced computed tomography (SPECT) in differentiating Alzheimer's disease (AD) from other dementias D.
  • High-dose B vitamin supplements do not slow cognitive decline in individuals with mild to moderate Alzheimer’s disease A.

Internet resources


Clinical practice reviews

  • Mayeux R. Clinical practice. Early Alzheimer's disease. N Engl J Med 2010 Jun 10;362(23):2194-201.  [PMID:20558370]
  • Raina P, Santaguida P, Ismaila A, Patterson C, Cowan D, Levine M, Booker L, Oremus M. Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med 2008 Mar 4;148(5):379-97  [PMID:18316756]

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