Evidence Summaries Anaesthetizing eardrops appear to be effective for sudden onset ear pain.
A Cochrane review 1 included 5 studies with a total of 391 children aged 3 to 18 years. 2 studies (n=117) compared anaesthetic ear drops versus placebo immediately at diagnosis. All children received some form of oral pain relief. There was a statistically significant difference in the proportion of children achieving a 50% reduction in pain in favour of anaesthetic drops 10 minutes after instillation (RR 2.13, 95% CI 1.19 to 3.80) and 30 minutes after instillation (RR 1.43, 95% CI 1.12 to 1.81) on the day acute otitis media (AOM) was diagnosed but not at 20 minutes (RR 1.24, 95% CI 0.88 to 1.74).
Three trials (with one common co-author) compared anaesthetic ear drops with naturopathic herbal ear drops in 274 patients. One of these trials also used antibiotics in both groups. Naturopathic drops were favoured 15 and 30 minutes after instillation, 1 to 3 days after diagnosis, but the differences were not statistically significant.
Comment: The quality of evidence is downgraded by study quality (unclear allocation concealment).
. Foxlee R, Johansson A, Wejfalk J, Dawkins J, Dooley L, Del Mar C. Topical analgesia for acute otitis media. Cochrane Database Syst Rev 2006 Jul 19;3:CD005657 [Last assessed as up-to-date: 10 February 2011]. [PMID:16856108]
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"Anaesthetizing Eardrops in the Treatment of Ear Pain." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/450899/all/Anaesthetizing_eardrops_in_the_treatment_of_ear_pain.
Anaesthetizing eardrops in the treatment of ear pain. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/450899/all/Anaesthetizing_eardrops_in_the_treatment_of_ear_pain. Accessed June 3, 2023.
Anaesthetizing eardrops in the treatment of ear pain. (2019). In Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited. https://evidence.unboundmedicine.com/evidence/view/EBMG/450899/all/Anaesthetizing_eardrops_in_the_treatment_of_ear_pain
Anaesthetizing Eardrops in the Treatment of Ear Pain [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2023 June 03]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/450899/all/Anaesthetizing_eardrops_in_the_treatment_of_ear_pain.
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