Evidence Summaries Immunotherapy reduces asthma symptoms and use of asthma medications and improves bronchial hyper-reactivity.
A Cochrane review 1 included 88 studies with a total of 3,792 subjects (3459 with asthma). Of the trials 42 were of immunotherapy for house mite allergy, 27 for pollen allergy, 10 for animal dander, 2 Cladosporium mould allergy, 2 latex and six trials looking at multiple allergens. Overall, there was a significant reduction in asthma symptoms and medication and improvement in bronchial hyper-reactivity following immunotherapy. There was a significant improvement in asthma symptom scores (standardised mean difference –0.59, 95% CI –0.83 to –0.35). NNT to avoid one deterioration in asthma symptoms was 3 (95% CI 3 to 5) and to avoid one requiring increased medication NNT was 4 (95% CI 3 to 6). Allergen immunotherapy significantly reduced allergen specific bronchial hyper-reactivity, with some reduction in non-specific bronchial hyper-reactivity as well. There was no consistent effect on lung function. If 16 patients were treated with immunotherapy, one would be expected to develop a local adverse reaction. If nine patients were treated with immunotherapy, one would be expected to develop a systemic reaction (of any severity).
. Abramson MJ, Puy RM, Weiner JM. Injection allergen immunotherapy for asthma. Cochrane Database Syst Rev 2010;(8):CD001186. [PMID:20687065]
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"Allergen Immunotherapy for Asthma." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/450291/all/__________Allergen_immunotherapy_for_asthma______.
Allergen immunotherapy for asthma. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/450291/all/__________Allergen_immunotherapy_for_asthma______. Accessed June 5, 2023.
Allergen immunotherapy for asthma. (2019). In Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited. https://evidence.unboundmedicine.com/evidence/view/EBMG/450291/all/__________Allergen_immunotherapy_for_asthma______
Allergen Immunotherapy for Asthma [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2023 June 05]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/450291/all/__________Allergen_immunotherapy_for_asthma______.
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