Allergen immunotherapy for asthma
Evidence Summaries Level of Evidence = A
Immunotherapy reduces asthma symptoms and use of asthma medications and improves bronchial hyper-reactivity.
A Cochrane review 1 included 88 studies with a total of 3,792 subjects (3459 with asthma). Of the trials 42 were of immunotherapy for house mite allergy, 27 for pollen allergy, 10 for animal dander, 2 Cladosporium mould allergy, 2 latex and six trials looking at multiple allergens. Overall, there was a significant reduction in asthma symptoms and medication and improvement in bronchial hyper-reactivity following immunotherapy. There was a significant improvement in asthma symptom scores (standardised mean difference –0.59, 95% CI –0.83 to –0.35). NNT to avoid one deterioration in asthma symptoms was 3 (95% CI 3 to 5) and to avoid one requiring increased medication NNT was 4 (95% CI 3 to 6). Allergen immunotherapy significantly reduced allergen specific bronchial hyper-reactivity, with some reduction in non-specific bronchial hyper-reactivity as well. There was no consistent effect on lung function. If 16 patients were treated with immunotherapy, one would be expected to develop a local adverse reaction. If nine patients were treated with immunotherapy, one would be expected to develop a systemic reaction (of any severity).
1. Abramson MJ, Puy RM, Weiner JM. Injection allergen immunotherapy for asthma. Cochrane Database Syst Rev 2010;(8):CD001186. [PMID:20687065].
Copyright © 2017 Duodecim Medical Publications Limited.
Evidence Central is an integrated web and mobile solution that helps clinicians quickly answer etiology, diagnosis, treatment, and prognosis questions using the latest evidence-based research. Learn more.