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Aerobic exercise, lipids and lipoproteins in overweight and obese adults

Evidence Summaries

Level of Evidence = B

 Aerobic exercise appears to produce a small decrease in triglyceride levels in overweight and obese adults, but the observed positive effect on total cholesterol is less clear.

A systematic review 1 including 13 studies with a total of 613 subjects was abstracted in DARE. Studies of interventions containing prescribed aerobic exercise of at least 8 weeks' duration compared with a non-exercise group were eligible for inclusion. Resistance training was excluded, as were studies that combined exercise with a dietary intervention. Statistically significant improvements for total cholesterol (X +/- s.e.m., - 3.4+/-1.7 mg/dl, 95% CI - 6.7 to - 0.2 mg/dl) and triglycerides (- 16.1+/-7.3 mg/dl, 95% CI - 30.2 to - 2.1 mg/dl) but not HDL (1.6+/-0.8 mg/dl, 95% CI - 0.02 to 3.2 mg/dl) or LDL (- 0.5+/-1.3 mg/dl, 95% CI - 3.0 to 2.0 mg/dl) were found. Changes were equivalent to improvements of 2% (total cholesterol), 11% (triglycerides), 3% (HDL), and 0.3% (LDL). After conducting sensitivity analyses, only decreases in triglycerides remained statistically significant. In SI units the observed improvements were 0.09 mmol/l for total cholesterol, 0.18 mmol/l for triglycerides, 0.04 mmol/l for HDL, and 0.01 mmol/l for LDL cholesterol.

Comment: The quality of evidence is downgraded by study quality (more than 20% loss to follow up).

References

1. Kelley GA, Kelley KS, Vu Tran Z. Aerobic exercise, lipids and lipoproteins in overweight and obese adults: a meta-analysis of randomized controlled trials. Int J Obes (Lond) 2005 Aug;29(8):881-93.  [PMID:15824746]


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Citation

"Aerobic Exercise, Lipids and Lipoproteins in Overweight and Obese Adults." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/450116/all/Aerobic_exercise__lipids_and_lipoproteins_in_overweight_and_obese_adults.
Aerobic exercise, lipids and lipoproteins in overweight and obese adults. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/450116/all/Aerobic_exercise__lipids_and_lipoproteins_in_overweight_and_obese_adults. Accessed August 18, 2019.
Aerobic exercise, lipids and lipoproteins in overweight and obese adults. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/450116/all/Aerobic_exercise__lipids_and_lipoproteins_in_overweight_and_obese_adults
Aerobic Exercise, Lipids and Lipoproteins in Overweight and Obese Adults [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 August 18]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/450116/all/Aerobic_exercise__lipids_and_lipoproteins_in_overweight_and_obese_adults.
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TY - ELEC T1 - Aerobic exercise, lipids and lipoproteins in overweight and obese adults ID - 450116 BT - Evidence-Based Medicine Guidelines UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/450116/all/Aerobic_exercise__lipids_and_lipoproteins_in_overweight_and_obese_adults PB - Duodecim Medical Publications Limited DB - Evidence Central DP - Unbound Medicine ER -