Acetaminophen and gastrointestinal side effects

Evidence Summaries

Level of Evidence = B

Acetaminophen (paracetamol) appears not to increase the risk of gastrointestinal bleeding.

The safety of acetaminophen has been shown in a large number of studies. In a Spanish study of 875 patients with upper gastrointestinal bleeding and 2682 hospital controls ¹, the odds ratio for acetaminophen did not significantly differ from 1, but for aspirin it was 7.2 and for piroxicam 19.1.

Comment: The quality of evidence is upgraded by strong association.

The following decision support rules contain links to this evidence summary:

Paracetamol is the recommended first line analgesic in patients with osteoarthritis http://www.ebmeds.org/ebmeds/ebmeds_home.asp...

References

1. Laporte JR, Carné X, Vidal X, Moreno V, Juan J. Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs. Catalan Countries Study on Upper Gastrointestinal Bleeding. Lancet 1991 Jan 12;337(8733):85-9. [PMID:1670734]

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Citation

"Acetaminophen and Gastrointestinal Side Effects." Evidence-Based Medicine Guidelines, Duodecim Medical Publications Limited, 2019. Evidence Central, evidence.unboundmedicine.com/evidence/view/EBMG/450099/all/Acetaminophen_and_gastrointestinal_side_effects.

Acetaminophen and gastrointestinal side effects. Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. https://evidence.unboundmedicine.com/evidence/view/EBMG/450099/all/Acetaminophen_and_gastrointestinal_side_effects. Accessed January 21, 2019.

Acetaminophen and gastrointestinal side effects. (2019). In Evidence-Based Medicine Guidelines. Available from https://evidence.unboundmedicine.com/evidence/view/EBMG/450099/all/Acetaminophen_and_gastrointestinal_side_effects

Acetaminophen and Gastrointestinal Side Effects [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim Medical Publications Limited; 2019. [cited 2019 January 21]. Available from: https://evidence.unboundmedicine.com/evidence/view/EBMG/450099/all/Acetaminophen_and_gastrointestinal_side_effects

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TY - ELEC T1 - Acetaminophen and gastrointestinal side effects ID - 450099 BT - Evidence-Based Medicine Guidelines UR - https://evidence.unboundmedicine.com/evidence/view/EBMG/450099/all/Acetaminophen_and_gastrointestinal_side_effects PB - Duodecim Medical Publications Limited DB - Evidence Central DP - Unbound Medicine ER -