Single dose oral meloxicam for acute postoperative pain in adults Stable (no update expected for reasons given in 'What's new')

Abstract

Abstract Background

Meloxicam is a non‐steroidal anti‐inflammatory drug (NSAID) used mainly in treating pain associated with arthritis. The usual oral dose for osteoarthritis is 15 mg daily, but lower doses of 7.5 mg are advised in older patients. This review sought to evaluate the efficacy and safety of oral meloxicam in acute postoperative pain, using clinical studies of patients with established pain, and with outcomes measured primarily over 6 hours using standard methods. This type of study has been used for many decades to establish that drugs have analgesic properties.

Objectives

To assess the efficacy of single dose oral meloxicam in acute postoperative pain, and any associated adverse events.

Search methods

We searched Cochrane CENTRAL (Issue 2, 2009), MEDLINE (June 2009); EMBASE (June 2009); the Oxford Pain Relief Database.

Selection criteria

Randomised, double‐blind, placebo‐controlled clinical trials of oral meloxicam for relief of acute postoperative pain in adults.

Data collection and analysis

Two review authors independently assessed trial quality and extracted data. We planned to use area under the "pain relief versus time" curve to derive the proportion of participants with meloxicam experiencing least 50% pain relief over 4 to 6 hours, using validated equations; to use number needed to treat to benefit (NNT); the proportion of participants using rescue analgesia over a specified time period; time to use of rescue analgesia; information on adverse events and withdrawals.

Main results

No studies were identified by the searches that examined oral meloxicam in patients with established postoperative pain.

Authors' conclusions

In the absence of evidence of efficacy, at present, for oral meloxicam in acute postoperative pain, its use in this indication is not justified. Because trials clearly demonstrating analgesic efficacy in the most basic of acute pain studies is lacking, use in other indications should be evaluated carefully. Given the large number of available drugs of this and similar classes, there is no urgent research agenda.

Author(s)

R Andrew Moore, Sheena Derry, Henry J McQuay

Abstract

Plain language summary

Single dose oral meloxicam for acute postoperative pain in adults

Pain is commonly experienced after surgical procedures. The condition is usually used to test whether or not drugs are effective painkillers in participants with moderate or severe pain. In this case we could find no studies that tested oral meloxicam against placebo. It is possible that the studies were done, but not reported, because they were used only to register meloxicam with licensing authorities throughout the world. However, this leaves an important gap in our knowledge, and it means that we cannot be confident about using oral meloxicam for acute painful conditions.

Author(s)

R Andrew Moore, Sheena Derry, Henry J McQuay

Reviewer's Conclusions

Authors' conclusions

Implications for practice

In the absence of evidence of efficacy for oral meloxicam in acute postoperative pain, its use in this indication is not justified. Because trials clearly demonstrating analgesic efficacy in the most basic of acute pain studies is lacking, use in other indications should be evaluated carefully.

Implications for research

Given the large number of available drugs of this and similar classes to treat postoperative pain, there is no urgent research agenda.

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