Patient controlled intravenous opioid analgesia versus continuous epidural analgesia for pain after intra-abdominal surgery: Cochrane systematic review

Abstract

Assessed as up to date: 2004/10/14

Background

There are two common techniques for postoperative pain control after intra-abdominal surgery: patient-controlled analgesia (PCA) with intravenous opioids and continuous epidural analgesia (CEA). It is uncertain which method has better pain control and fewer adverse effects.

Objectives

The objective of this review was to compare PCA opioid therapy with CEA for pain control after intra-abdominal surgery in terms of analgesic efficacy, side effects, patient satisfaction and surgical outcome by meta-analysis of the relevant trials.

Search methods

We searched CENTRAL (The Cochrane Library Issue 4, 2002), MEDLINE (January 1966 to October 2002), EMBASE (January 1988 to October 2002), and reference lists of articles. We also contacted researchers in the field.

Selection criteria

Randomized controlled trials of adult patients after intra-abdominal surgery comparing the effect of two pain control regimens in terms of analgesic efficacy and side effects. In the patient-controlled analgesia (PCA) group the patient should be able to operate the device himself. In the continuous epidural analgesia group there was no PCA device.

Data collection and analysis

Two authors independently assessed trial quality and extracted data. Study authors were contacted for additional information. Adverse effects information was collected from the trials.

Main results

Nine studies involving 711 participants were included. The PCA group had a higher pain visual analogue scale than the CEA group during 6, 24 and 72 hour periods. The weighted mean difference and 95% confidence interval of resting pain was 1.74 (95% CI 1.30 to 2.19), 0.99 (95% CI 0.65 to 1.33), and 0.63 (95% CI 0.24 to 1.01), respectively. The length of hospital stay and other adverse effects were not statistically different except that the incidence of pruritus was lower in the PCA group, odds ratio of 0.27 (95% CI 0.11 to 0.64).

Authors' conclusions

CEA is superior to opioid PCA in relieving postoperative pain for up to 72 hours in patients undergoing intra-abdominal surgery, but it is associated with a higher incidence of pruritus. There is insufficient evidence to draw comparisons about the other advantages and disadvantages of these two methods of pain relief.

Author(s)

Werawatganon Thewarug, Charuluxananan Somrat

Summary

Continuous epidural analgesia is superior to intravenous opioid patient-controlled analgesia in relieving postoperative pain for up to 72 hours after abdominal surgery

Continuous epidural analgesia (CEA) is more effective than intravenous opioid patient-controlled analgesia (PCA) in relieving postoperative pain for up to 72 hours after abdominal surgery. CEA is associated with a higher incidence of generalized itching than PCA. There is insufficient evidence to draw comparisons about the other advantages and disadvantages of these two methods of pain relief.

Reviewer's Conclusions

Implications for practice

In patients undergoing intra-abdominal surgery, CEA is superior to opioid PCA in relieving postoperative pain for up to 72 hours but it is associated with a higher incidence of pruritus. There is insufficient evidence of any other advantage of CEA over PCA.

Implications for research

Further research is needed into advantages of CEA over PCA for intra-abdominal pain control. A study should be conducted focusing on complications: for example, pulmonary complications, such as respiratory depression or pulmonary atelectasis. Clinical trials should record and present outcomes in values that are appropriate for meta-analysis.

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TY - ELEC T1 - Patient controlled intravenous opioid analgesia versus continuous epidural analgesia for pain after intra-abdominal surgery: Cochrane systematic review ID - 431186 BT - Cochrane Abstracts UR - https://evidence.unboundmedicine.com/evidence/view/Cochrane/431186/all/Patient_controlled_intravenous_opioid_analgesia_versus_continuous_epidural_analgesia_for_pain_after_intra_abdominal_surgery:_Cochrane_systematic_review DB - Evidence Central DP - Unbound Medicine ER -