Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis New search for studies and content updated (no change to conclusions)

Abstract

Abstract Background

Chest physiotherapy is widely prescribed to assist the clearance of airway secretions in people with cystic fibrosis (CF). Positive expiratory pressure (PEP) devices provide back pressure to the airways during expiration. This may improve clearance by building up gas behind mucus via collateral ventilation and by temporarily increasing functional residual capacity. The developers of the PEP technique recommend using PEP with a mask in order to avoid air leaks via the upper airways and mouth. In addition, increasing forced residual capacity (FRC) has not been demonstrated using mouthpiece PEP. Given the widespread use of PEP devices, there is a need to determine the evidence for their effect. This is an update of a previously published review.

Objectives

To determine the effectiveness and acceptability of PEP devices compared to other forms of physiotherapy as a means of improving mucus clearance and other outcomes in people with CF.

Search methods

We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register comprising of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. The electronic database CINAHL was also searched from 1982 to 2017.

Most recent search of the Group's CF Trials Register: 20 February 2019.

Selection criteria

Randomised controlled studies in which PEP was compared with any other form of physiotherapy in people with CF. This included, postural drainage and percussion (PDPV), active cycle of breathing techniques (ACBT), oscillating PEP devices, thoracic oscillating devices, bilevel positive airway pressure (BiPaP) and exercise.

Data collection and analysis

Three authors independently applied the inclusion and exclusion criteria to publications, assessed the risk of bias of the included studies and assessed the quality of the evidence using the GRADE recommendations.

Main results

A total of 28 studies (involving 788 children and adults) were included in the review; 18 studies involving 296 participants were cross‐over in design. Data were not published in sufficient detail in most of these studies to perform any meta‐analysis. In 22 of the 28 studies the PEP technique was performed using a mask, in three of the studies a mouthpiece was used with nose clips and in three studies it was unclear whether a mask or mouthpiece was used. These studies compared PEP to ACBT, autogenic drainage (AD), oral oscillating PEP devices, high‐frequency chest wall oscillation (HFCWO) and BiPaP and exercise.

Forced expiratory volume in one second was the review's primary outcome and the most frequently reported outcome in the studies (24 studies, 716 participants). Single interventions or series of treatments that continued for up to three months demonstrated little or no difference in effect between PEP and other methods of airway clearance on this outcome (low‐ to moderate‐quality evidence). However, long‐term studies had equivocal or conflicting results regarding the effect on this outcome (low‐ to moderate‐quality evidence).

A second primary outcome was the number of respiratory exacerbations. There was a lower exacerbation rate in participants using PEP compared to other techniques when used with a mask for at least one year (five studies, 232 participants; moderate‐ to high‐quality evidence). In one of the included studies which used PEP with a mouthpiece, it was reported (personal communication) that there was no difference in the number of respiratory exacerbations (66 participants, low‐quality evidence).

Participant preference was reported in 10 studies; and in all studies with an intervention period of at least one month, this was in favour of PEP. The results for the remaining outcome measures (including our third primary outcome of mucus clearance) were not examined or reported in sufficient detail to provide any high‐quality evidence; only very low‐ to moderate‐quality evidence was available for other outcomes. There was limited evidence reported on adverse events; these were measured in five studies, two of which found no events. In a study where infants performing either PEP or PDPV experienced some gastro‐oesophageal reflux , this was more severe in the PDPV group (26 infants, low‐quality evidence). In PEP versus oscillating PEP, adverse events were only reported in the flutter group (five participants complained of dizziness, which improved after further instructions on device use was provided) (22 participants, low‐quality evidence). In PEP versus HFCWO, from one long‐term high‐quality study (107 participants) there was little or no difference in terms of number of adverse events; however, those in the PEP group had fewer adverse events related to the lower airways when compared to HFCWO (high‐certainty evidence).

Many studies had a risk of bias as they did not report how the randomisation sequence was either generated or concealed. Most studies reported the number of dropouts and also reported on all planned outcome measures.

Authors' conclusions

The evidence provided by this review is of variable quality, but suggests that all techniques and devices described may have a place in the clinical treatment of people with CF.

Following meta‐analyses of the effects of PEP versus other airway clearance techniques on lung function and patient preference, this Cochrane Review demonstrated that there was high‐quality evidence that showed a significant reduction in pulmonary exacerbations when PEP using a mask was compared with HFCWO. It is important to note that airway clearance techniques should be individualised throughout life according to developmental stages, patient preferences, pulmonary symptoms and lung function. This also applies as conditions vary between baseline function and pulmonary exacerbations.

Author(s)

Maggie McIlwaine, Brenda Button, Sarah J Nevitt

Abstract

Plain language summary

Using positive expiratory pressure physiotherapy to clear the airways of people with cystic fibrosis

Review question

We reviewed the evidence on the effect of positive expiratory pressure (PEP) physiotherapy to clear the airways of people with cystic fibrosis (CF).

Background

CF affects approximately one in 3000 live births in white populations and causes frequent lung infection, due to mucus blocking the airways. Chest physiotherapy is often used to try to clear the mucus from the lungs. We wanted to discover whether using a PEP device (a form of chest physiotherapy) was better or worse than other other forms of chest physiotherapy for clearing the mucus from the lungs in people with CF. A PEP device provides positive pressure behind the mucus to try to push it out of the lungs. This is an update of a previously published review.

Search date

The evidence is current to 20 February 2019.

Study characteristics

The review includes 28 studies with 788 people (from infants to adults) with CF with mild to severe lung disease. The studies compared PEP to other methods of chest physiotherapy; the length of treatment ranged from a single session to two years of treatment.

Key results

Generally, the efficacy of PEP is similar to other methods of chest physiotherapy such as postural drainage with percussion, active cycle of breathing techniques, autogenic drainage, oscillatory PEP devices such as the flutter and acapella, thoracic oscillating devices such as the 'Vest', and bilevel positive airway pressure (BiPaP) (typically used for ventilatory support, but by changing the inspiratory and expiratory pressures on the device and combining it with huffing, BiPaP has been used for airway clearance). We found no difference between PEP and other forms of chest physiotherapy in lung function, the amount of mucus cleared from the airways or its related effects on the health of people with CF. However, the rate of flare ups of respiratory symptoms decreased in people using PEP compared to other forms of physiotherapy such as a vibrating PEP device or a vibrating vest. There was some evidence that people with CF may prefer PEP to other chest physiotherapy methods. There was no evidence of PEP causing harm, except in one study where infants performing either PEP or percussion in various positions which use gravity to help drain secretions, experienced some gastro‐oesophageal reflux (regurgitation of food) in head‐down positions; this was more severe in the group using postural drainage with percussion. In all the other trials PEP was performed in a sitting position.

In 10 of the 28 studies studied single PEP treatment sessions. The results from these studies are very limited as they could not report on the number of respiratory infections and lung function did not change with just one treatment. Two one‐year studies compared PEP to postural drainage and percussion; in the study with children, PEP improved their lung function, while in the adult study, lung function declined slightly with both PEP and postural drainage and percussion. Also, the method of performing PEP was different in the two age groups.

Although PEP seems to have an advantage in reducing flare ups (based on the combined results of a few studies), different physiotherapy techniques and devices may be more or less effective at varying times and in different individuals during baseline function and chest flare ups. Each person should talk to their clinician to help choose which method of airway clearance is best for them and which they will adhere to, so as to provide the best quality of life and long‐term outcomes.

Quality of the evidence

Some studies were of low quality. These studies highlight the difficulty in comparing studies using PEP compared to other forms of chest physiotherapy. Factors such as age and severity of lung disease in the participants may affect the results as well as the method of performing each treatment. Overall, the evidence provided by this review for whether PEP reduces flare ups compared to other forms of chest physiotherapy was moderate to high quality, but evidence for other outcomes was of very low to moderate quality, as results were limited.

Author(s)

Maggie McIlwaine, Brenda Button, Sarah J Nevitt

Reviewer's Conclusions

Authors' conclusions

Implications for practice

The quality of the evidence varied between studies carried out over a few days to well‐designed year‐long randomised controlled trials; however, the evidence from the studies described in this updated Cochrane Review suggests that all techniques and devices may have a place in the clinical treatment of patients with cystic fibrosis (CF). In relation to respiratory exacerbations, high‐quality evidence (a long‐term multicentre study across all ages) showed that, when compared to high‐frequency chest wall oscillation (HFCWO), positive expiratory pressure (PEP) using a mask reduced respiratory exacerbations.. There was some evidence to recommend PEP as a more acceptable intervention long term than other forms of physiotherapy for people with CF. However, the evidence that PEP was preferred over other techniques came from studies which were generally of low quality. Airway clearance techniques should be individualised throughout life according to developmental stages, patient choice, pulmonary symptoms and lung function. They may need to be varied during pulmonary exacerbations versus baseline function. It should be noted that although PEP via a mouthpiece system is commonly used, most of the literature pertains to PEP using a mask. The mouthpiece has not shown to increase FRC in the manner achieved by mask PEP and there is ambiguity around opportunity for upper airway air leaks when using a mouthpiece.

Implications for research

Short‐term interventions on stable participants may be of little value given the nature of CF lung disease which frequently follows a chronic course with acute exacerbations. Future studies should be planned to reflect clinical practice by focusing on short‐term interventions during exacerbations or long term studies on initially stable patients.

Blinding of researchers and participants in studies comparing different airway clearance techniques is not possible. However, blinded assessors have been utilised in a number of the reviewed studies which increases the quality of the evidence and reduces the risk of bias. Blinded assessors should be involved in all future studies which may have resource and cost implications which should be considered when planning studies.

Cross‐over studies are not the best design for clinical studies in CF due to the unstable nature of the disease (Southern 2003). They may be influenced by carry‐over effects. Future parallel, randomised clinical studies comparing PEP with other airway clearance modalities are needed. These studies should be adequately powered and a multicentre approach may facilitate this. Such studies should in particular, examine the influence of PEP and other therapies on lung function parameters, quality of life, exercise tolerance, cost and survival.

The abstract format often prevents evaluation of the scientific methodology of the study. Abstracts should be structured to contain essential information about method and results. The large proportion of studies which were published only as abstracts highlights the need for full publication in peer reviewed journals.

The studies in this review frequently found no significant difference in efficacy between treatments. Expectorated sputum measures may be confounded by expectorated saliva, swallowed secretions and regurgitated contents and are generally regarded as less useful outcomes than measurement of mucociliary clearance. Sputum rheology differs between individuals with CF and between different organisms. Research to determine the best technique for situations where sputum is thin and liquid versus thick and viscous may be a new area for more targeted research and application of different techniques in different patients.

Exacerbation rate and time to first exacerbation in longer term trials (at least 12 months) between compared airway clearance techniques may be of greater use and relevance in CF, a long‐term disease. Future studies should include validated measures of patient preference including treatment time (a potential barrier to adherence) as this may assist in determining a suitable treatment when measures of efficacy are equivocal. Similarly, cost and adverse effect outcome data would assist consumers in decision‐making. Studies that broaden the knowledge of the effects of different techniques on different aspects of the pathophysiology of CF will progress the aspiration for evidence based physiotherapy in CF.

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