Acute coronary syndrome
270 results
131 - 230Low-dose rivaroxaban improves outcomes in patients with ACS (ATLAS)
Accelerated protocol identifies chest pain patients at low risk for major cardiac events
Antithrombotic agents in primary health care
Drug-eluting stents versus bare metal stents for angina or acute coronary syndromes: Cochrane systematic review
ACC/AHA guideline for the management of patients with chronic coronary disease
Concomitant use of clopidogrel and a PPI may increase risk of adverse CHD outcomes
Apixaban increases bleeding with no benefit in high-risk patients with ACS
ED chest pain protocol is safe and efficient
Better medication adherence with intervention; clinical outcomes unchanged
Exercise stress test
For atrial fibrillation with ACS or PCI, apixaban plus clopidogrel (without aspirin) is preferred (AUGUSTUS)
Intensive lipid lowering reduces mortality following ACS
ACS risk similar with normal ECG performed during presence or absence of chest pain
Low HS-troponin I accurate in identifying patients at low risk of cardiac events
Treatment of a near-drowning person
CCTA reduces need for hospitalization in low to moderate risk patients in ED
Platelet-function testing doesn't improve outcomes in elderly patients with stents after ACS
Mortality rate in patients with recent ACS and endoscopy is similar to that in patients with ACS and no endoscopy
Fewer major cardiac events with routine percutaneous coronary intervention in patients undergoing transcatheter aortic-valve implantation (NOTION-3)
High-sensitivity troponin I of less than 5 ng/L has negative predictive value of 99.9% for cardiac death at 1 year
Clinical decision rules for evaluating adults with chest pain in primary care are limited in number and utility — stay tuned
Two-hour protocol identifies patients at low risk of ACS
Routine stress testing after negative biomarker testing seldom helpful
Intensive versus moderate statin therapy
Restrictive transfusion strategy is best for hospitalized patients
Small study finds recurrent spontaneous coronary artery dissection risk not associated with subsequent pregnancy
Adding ezetimibe to moderate-dose statin reduces nonfatal MI only (NNT = 58 for 6 years)
Percutaneous transluminal coronary angioplasty with stents versus coronary artery bypass grafting for people with stable angina or acute coronary syndromes
Intensive BP control modestly decreased the likelihood of a broad composite of CV events, but with methodologic limitations
Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events
Clopidogrel plus aspirin vs aspirin alone for preventing cardiovascular events
Echocardiography as an outpatient procedure
Clopidogrel monotherapy more effective than aspirin to prevent coronary events after PCI with drug-eluting stents (HOST-EXAM)
Percutaneous coronary intervention does not improve outcomes for patients with ischemic heart disease and LVEF of less than 35%
Coronary sinus-reducing device improves symptoms for patients with refractory angina
Similar outcomes after PCI in hospitals with or without on-site cardiac surgery (CPORT-E)
Overuse alert: treat-to-target LDL strategy of statin dosing is noninferior to high-intensity dosing
For atrial fibrillation with stable coronary artery disease, edoxaban alone prevents more bad outcomes than edoxaban plus an antiplatelet agent
Drug treatment for hypertension
Ticagrelor (Brilinta) is no better than aspirin—and may be worse—for adults after CABG
Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND)
In low-risk patients with ACS, noninvasive testing adds little to clinical evaluation
B vitamins, fish oil do not prevent CV events
Adding CCTA to chest pain assessment reduces likelihood of nonfatal MI (SCOT-HEART)
Corticosteroids for the treatment of Kawasaki disease in children
Systemic lupus erythematosus (SLE)
Dyspnoea
Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease
Flu vaccine reduces risk of adverse CV events in high-risk patients
Faster discharge but more downstream testing with use of CCTA in ED
Traditional approach to pretest probability of heart disease overestimates risk
Pioglitazone does not increase cardiovascular events (PROactive)
6-month clopidogrel better than 24 after stent placement (PRODIGY)
Little if any benefit to early invasive strategy for stable angina and at least moderate reversible ischemia (ISCHEMIA trial)
High-sensitivity troponin safely reduces admissions and duration of stay in the emergency department
Less is more when it comes to blood transfusions
Niacin not effective in CAD with low HDL cholesterol (AIM-HIGH)
Similar number of cardiovascular events and reduced bleeding with abbreviated dual antiplatelet therapy after PCI
In patients with vascular disease, treating sleep apnea does not reduce the risk of cardiovascular events
Lipid lowering is beneficial for secondary prevention but not primary prevention in patients 75 years and older
Dialysate temperature reduction for intradialytic hypotension for people with chronic kidney disease requiring haemodialysis
Interpretation of adult ECG
COVID-19 and other coronavirus infections
Clarithromycin associated with cardiovascular events
Increased readmissions and adverse events with intensification of antihypertensive regimen on hospital discharge
Promoting patient utilisation of cardiac rehabilitation
Small reduction in CV outcome after ischemic stroke with lower LDL target, but also harms; no change in all-cause mortality
Hyperbaric oxygen therapy (HBOT)
No reduction in postdischarge medication errors after pharmacist-led intervention
Antiplatelet agents for chronic kidney disease
Acute abdomen in the adult
Acute heart failure and pulmonary oedema
AABB recommends restrictive transfusion strategy for hospitalized patients
Ipratropium associated with increase risk of CV events
Taking furosemide on day of surgery does not increase intraop hypotension
SBP of 120 instead of 140 in adults 75 years or older = significant benefits and some harms (SPRINT)
Interpreting BNP in patients with a history of HF
SBP of 120 instead of 140 in nondiabetic, high-risk elderly leads to significant benefits and some harms (SPRINT)
Single nondetectable high-sensitivity troponin result rules out AMI
Sotagliflozin reduces hospitalizations and urgent visits in patients with T2DM and recent HF hospitalization (SOLOIST-WHF)
Restrictive transfusion strategies are appropriate for most critically ill patients with varying levels of evidence
Syncope: causes and investigations