Acute coronary syndrome
270 results
101 - 200ED chest pain protocol is safe and efficient
No reduction in postdischarge medication errors after pharmacist-led intervention
Routine stress testing after negative biomarker testing seldom helpful
Two-hour protocol identifies patients at low risk of ACS
Better medication adherence with intervention; clinical outcomes unchanged
Pain severity does not predict outcomes with AMI
Flu vaccine reduces risk of adverse CV events in high-risk patients
Dyspepsia
Early invasive therapy better for non-ST ACS
Concomitant use of clopidogrel and a PPI may increase risk of adverse CHD outcomes
Apixaban increases bleeding with no benefit in high-risk patients with ACS
Low molecular weight heparins versus unfractionated heparin for acute coronary syndromes: Cochrane systematic review
ACC/AHA guidelines on dual antiplatelet therapy
Bivalirudin = abciximab + heparin for non-STEMI
CCTA reduces need for hospitalization in low to moderate risk patients in ED
Fondaparinux for acute coronary syndromes
In low-risk patients with ACS, noninvasive testing adds little to clinical evaluation
Antithrombotic agents in primary health care
For atrial fibrillation with ACS or PCI, apixaban plus clopidogrel (without aspirin) is preferred (AUGUSTUS)
In ACS, 5 yrs of invasive tx decreases MI but not all cause mortality (FRISC-II)
Platelet-function testing doesn't improve outcomes in elderly patients with stents after ACS
ACS risk similar with normal ECG performed during presence or absence of chest pain
Adding ezetimibe to moderate-dose statin reduces nonfatal MI only (NNT = 58 for 6 years)
Evacetrapib increases HDL but does nothing for patient-oriented outcomes
Interpretation of adult ECG
Faster discharge but more downstream testing with use of CCTA in ED
Mortality rate in patients with recent ACS and endoscopy is similar to that in patients with ACS and no endoscopy
Low-dose rivaroxaban improves outcomes in patients with ACS (ATLAS)
Accelerated protocol identifies chest pain patients at low risk for major cardiac events
Drug-eluting stents versus bare metal stents for angina or acute coronary syndromes: Cochrane systematic review
ACC/AHA guideline for the management of patients with chronic coronary disease
Exercise stress test
Intensive lipid lowering reduces mortality following ACS
Low HS-troponin I accurate in identifying patients at low risk of cardiac events
Treatment of a near-drowning person
Fewer major cardiac events with routine percutaneous coronary intervention in patients undergoing transcatheter aortic-valve implantation (NOTION-3)
High-sensitivity troponin I of less than 5 ng/L has negative predictive value of 99.9% for cardiac death at 1 year
Clinical decision rules for evaluating adults with chest pain in primary care are limited in number and utility — stay tuned
Intensive versus moderate statin therapy
Restrictive transfusion strategy is best for hospitalized patients
Small study finds recurrent spontaneous coronary artery dissection risk not associated with subsequent pregnancy
Percutaneous transluminal coronary angioplasty with stents versus coronary artery bypass grafting for people with stable angina or acute coronary syndromes
Intensive BP control modestly decreased the likelihood of a broad composite of CV events, but with methodologic limitations
Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events
Clopidogrel plus aspirin vs aspirin alone for preventing cardiovascular events
Echocardiography as an outpatient procedure
Clopidogrel monotherapy more effective than aspirin to prevent coronary events after PCI with drug-eluting stents (HOST-EXAM)
Percutaneous coronary intervention does not improve outcomes for patients with ischemic heart disease and LVEF of less than 35%
Coronary sinus-reducing device improves symptoms for patients with refractory angina
Similar outcomes after PCI in hospitals with or without on-site cardiac surgery (CPORT-E)
Overuse alert: treat-to-target LDL strategy of statin dosing is noninferior to high-intensity dosing
For atrial fibrillation with stable coronary artery disease, edoxaban alone prevents more bad outcomes than edoxaban plus an antiplatelet agent
Drug treatment for hypertension
Ticagrelor (Brilinta) is no better than aspirin—and may be worse—for adults after CABG
Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND)
B vitamins, fish oil do not prevent CV events
Adding CCTA to chest pain assessment reduces likelihood of nonfatal MI (SCOT-HEART)
Corticosteroids for the treatment of Kawasaki disease in children
Systemic lupus erythematosus (SLE)
Dyspnoea
Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease
Traditional approach to pretest probability of heart disease overestimates risk
Pioglitazone does not increase cardiovascular events (PROactive)
6-month clopidogrel better than 24 after stent placement (PRODIGY)
Little if any benefit to early invasive strategy for stable angina and at least moderate reversible ischemia (ISCHEMIA trial)
High-sensitivity troponin safely reduces admissions and duration of stay in the emergency department
Less is more when it comes to blood transfusions