Vasopressors for shock
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Vasopressors for shock 
Vasopressors for hypotensive shock Edited (no change to conclusions)
Angiotensin II increases BP in vasodilatory shock resistant to high-dose vasopressors- External cooling improves short-term outcomes in pts with septic shock
- Early goal-directed therapy using central venous hemodynamic targets in septic shock does not reduce deaths
- Lower risk of atrial fibrillation with addition of vasopressin to catecholamines for treatment of shock
- No survival benefit with early goal-directed therapy for septic shock
- Prehospital emergency care
- More data suggest usual care is as good as EGDT (ProMISe)
- Higher BP target does not reduce mortality in septic patients (SEPSISPAM)
- Recombinant human activated Protein C does not reduce mortality in patients with septic shock (PROWESS-SHOCK)
- Intra‐aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock New search for studies and content updated (no change to conclusions)
- Early hydrocortisone ineffective in improving outcomes in patients with septic shock
- No mortality benefit and higher costs with early goal-directed therapy for septic shock
- Mixed results from studies of steroids for septic shock (APROCCHSS, ADRENAL)
- Tight glucose control ineffective in critically ill septic patients treated with corticosteroids
- No reduction in delirium with the use of haloperidol or ziprasidone in critically ill patients
- Mechanical assist devices for acute cardiogenic shock New
- Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome New search for studies and content updated (conclusions changed)
- PPI use in ICU for high-risk patients: less bleeding but no effect on mortality
- PEEP titration increases mortality in patients with ARDS compared with standard low PEEP
- Automated monitoring compared to standard care for the early detection of sepsis in critically ill patients Edited (no change to conclusions)