Aspirin for the primary prevention of cardiovascular events
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Aspirin for the primary prevention of cardiovascular events 
USPSTF 2022 recommends against initiating aspirin for primary prevention of cardiovascular disease in adults 60+ years (D recommendation)- Low-dose aspirin not effective for primary prevention of CV events (again) and increases risk of serious bleeding
- ASA: not for primary prevention
- Low-dose aspirin for primary prevention of vascular events in type 2 diabetes
- The balance of benefits and harms no longer favors aspirin for primary prevention
- Antithrombotic agents in primary health care
- Effectiveness of aspirin in primary prevention appears to vary by patient weight
- Aspirin's benefits and harms are less clear for primary prevention in moderate-risk patients (ARRIVE)
- Diabetes no longer a specific indication for ASA use
- ASA of limited benefit in patients with diabetes
- Rivaroxaban + aspirin somewhat better than aspirin alone for tertiary prevention of CVD (COMPASS)
- Aspirin following anticoagulation therapy prevents recurrent VTE (ASPIRE)
Antiplatelet agents and anticoagulants for hypertension- Benefit of low-dose aspirin for type 2 diabetes is uncertain
- Antiplatelet agents for preventing thrombosis after peripheral arterial bypass surgery
- Cerebral infarction (ischaemic stroke)
- Transient ischaemic attack (TIA)
- Antiplatelet agents for chronic kidney disease
- Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia
- Antiplatelet agents for preventing thrombosis after peripheral arterial bypass surgery
- Low-dose rivaroxaban improves outcomes in patients with ACS (ATLAS)
- Chuanxiong preparations for preventing stroke: Cochrane systematic review
- Rivaroxaban + clopidogrel causes somewhat less bleeding than triple therapy in patients with AF undergoing PCI
- For atrial fibrillation with ACS or PCI, apixaban plus clopidogrel (without aspirin) is preferred (AUGUSTUS)
- Lenient = strict rate control in prevention of adverse outcomes in AF
- ** Update Information **