Levels of Evidence
204 results
1 - 100
Levels of Evidence- Restrictive transfusion strategies are appropriate for most critically ill patients with varying levels of evidence
- USPSTF: no evidence of benefit from screening for thyroid disease
- USPSTF 2019: insufficient evidence to recommend lead screening in children and pregnant women (I statement)
- Limited evidence of benefits of vitamin D supplementation
- No evidence that dupilumab is effective as add-on therapy in mod-severe asthma with eosinophilia
- Sodium supplementation as an adjunct to furosemide in acute decompensated heart failure leads to weight loss and decreased length of stay
- More evidence that even small amounts of caffeine consumption during pregnancy affect childhood growth
- SR: poor quality evidence on outcomes of lactate point-of-care testing in patients with suspected sepsis
- USPSTF 2017 finds uncertain benefit of behavioral counseling for low-risk adults without obesity (C recommendation)
- DHEA, testosterone not effective in aging patients
- Do not treat subclinical hypothyroidism in most patients
- Diabetes alone is NOT a coronary risk equivalent to a history of myocardial infarction
- Low magnesium level not related to hypertension or CVD
- American College of Physicians: Limit testosterone supplementation in older men to the treatment of sexual function issues
- COVID-19 research briefs: prediction models for COVID-19 have important limitations
- Useful clinical indicators to diagnose cirrhosis
- Heart and diabetes groups suggest there is little association between A1C levels and CVD risk
- USPSTF 2018: insufficient evidence to recommend nontraditional risk factors for CVD screening (I statement)
- NICE guidelines for diabetes mellitus, type 2
- USPSTF: Evidence insufficient to recommend routine screening for suicide risk
- Cardiac troponin often falsely elevated in patients at low risk
- Minimal, if any, cardiovascular benefit from intravenous iron for adults with heart failure and iron deficiency
- Effect of anacetrapib on patient-oriented outcomes remains uncertain
- Increased mortality with K <3.5 or >4.5 in patients hospitalized with acute MI
- Statins effective for LDL 190 mg/dL or higher, regardless of risk level
- Treatment of acne rosacea should be based on the phenotype: best evidence summary
- Subclinical hypothyroidism associated with increased risk of CHD
- ACP Guideline: Intensive insulin therapy not recommended for ICU patients
- USPSTF 2022: updated review of statins for the primary prevention of cardiovascular disease
- Guideline for chronic diarrhea: screening for IBD and celiac disease is in, screening for ova and parasites is out
- Tenuous link between vitamin D and chronic pain
- Useful history, physical, and laboratory findings for predicting secondary hypertension in children and adolescents
- Many recommendations from TV docs are not based on evidence
- Despite no evidence, the ATS issues a guideline on managing obesity hypoventilation syndrome
- BNP testing does not decrease hospitalization rate
- Low-quality evidence supports exercise, massage, yoga, acupuncture, and other interventions for chronic pain
- Lowering homocysteine with B vitamins doesn't improve cognition
- USPSTF: No recommendation for lipid disorder screening in patients 20 years or younger (I recommendation)
- USPSTF 2022: Insufficient evidence of benefit vs harm of screening for type 2 diabetes in children and adolescents (I statement)
- Nondrug therapy preferred for low back pain: American College of Physicians
- Long-term use of PPIs appears to be safe in children
- Delayed cord clamping in full-term infants reduces risk of anemia
- Vitamin D supplementation does not prevent diabetes
- High-dose B vitamins do not slow cognitive decline in adults with AD
- USPSTF 2021 recommends oral fluoride supplementation and fluoride varnish application to prevent caries in children (B recommendation)
- More nuanced guidelines for lipid lowering to prevent CV disease
- USPSTF 2023: Evidence insufficient to recommend lipid screening in children and adolescents (I statement)
- Treating low vitamin D levels is ineffective in postmenopausal women
- Most tests for rotator cuff disease are inaccurate
- Best way to perform lumbar puncture and analyze results
- Intensive control of blood sugar (HbA1c < 7.0%) in DM2 may be harmful (ACCORD)
- Home sleep apnea tests are moderately accurate; depends on cutoff and baseline risk
- Colon CA unlikely if unexplained anemia but ferritin >100 ng/mL
- Testosterone therapy may reduce symptoms of depression in men
- AABB recommends restrictive transfusion strategy for hospitalized patients
- Guidelines for osteoporosis screening (USPSTF)
- Stent retriever therapy added to tPA is effective for treatment of acute ischemic stroke
- Endocrine Society: Kids, and adults who are pregnant, have pre-diabetes, and are older than 74 years may benefit from empiric vitamin D
- Transdermal testosterone does not improve libido in female cancer survivors
- USPSTF 2016: screening for syphilis in adults and adolescents at increased risk
- Gestational diabetes screening: Insufficient evidence of benefit
- CV interventions in old elderly are not useful (DEBATE)
- Convalescent plasma does not decrease deaths or mechanical ventilation in patients with COVID-19, hypoxia, and elevated CRP levels (RECOVERY)
- Transient glucose elevations in DM patients receiving epidural steroid injections
- Active management is more effective than expectant management for resolution of nonviable pregnancy of unknown location
- No significant differences with liberal vs restrictive transfusion strategies for patients hospitalized with MI and anemia (MINT)
- Type 2 diabetes: metformin first, other treatments second
- Motivational interviewing increases physical activity, but the certainty of evidence is low
- Long-term results of drug treatment for obesity
- Peanut and tree nut consumption during pregnancy may decrease risk of allergic disease in children
- Vitamin D does not prevent ARTI or asthma exacerbation in vitamin D–deficient patients
- Guidelines: Management of RA
- Early return to activity improves symptoms in children with concussion
- Vitamin D does not reduce the incidence or severity of URIs in healthy adults
- Overuse alert: treat-to-target LDL strategy of statin dosing is noninferior to high-intensity dosing
- USPSTF 2016 recommendations on statin use for primary prevention of CVD
- Pioglitazone exposure increases bladder cancer risk
- No worsening of post-op atrial arrhythmias with relaxed potassium supplementation following coronary artery bypass grafting (TIGHT K)
- No benefit to maintaining higher hemoglobin levels in hip surgery patients at high CV risk (FOCUS)