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In adults with atrial fibrillation and acute ischemic strokes, early (within 4 days) and delayed (7-10 days) initiation of DOACs have similar outcomes (OPTIMAS)- AHA guideline for secondary stroke prevention
- Clinical factors poorly predict ICH in stroke patients undergoing thrombolysis
- Low-intensity warfarin may be inferior to standard-intensity warfarin for preventing VTE after joint arthroplasty
- Direct oral anticoagulants associated with better outcomes than warfarin in older patients with stroke and AF (PROSPER)
- Endovascular therapies do not improve outcomes in acute stroke
- For patients with ARDS, conservative oxygen strategy is no better, and may be worse, than a more liberal strategy (LOCO2)
- Early anticoagulation after ischemic stroke is a safe strategy (ELAN)
- Lower costs and healthcare utilization with hospital care at home