Angioedema
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Lanadelumab is an effective prophylactic treatment for hereditary angioedema- Icatibant more effective than standard therapy for ACEI-induced angioedema
- Easy rule identifies patients with low-risk penicillin allergies
- PEN-FAST score to predict penicillin allergy not useful in pediatric population
- ACE = ARB for secondary CV prevention; combination worse (ONTARGET)
- Steroid treatment adds no benefit to antihistamines for acute hives
- Valsartan/sacubitril reduces mortality more than enalapril 10 mg twice daily in patients with heart failure (PARADIGM-HF)
- Hi-dose ARB slightly better than standard dose in pts with CHF (HEAAL)
- Peanut desensitization therapy increases anaphylactic reactions compared with placebo or avoidance
- Intensive blood pressure lowering decreases cardiovascular events (NNT = 58) and increases hypotension and syncope (NNTH = 55)