Minocycline appears to be effective for moderate to moderately-severe inflammatory acne vulgaris, but there is no evidence that it is better than any of the other commonly-used acne treatments, and concerns remain about its safety compared to other tetracyclines [Evidence Level: B].
There is not enough data to evaluate the effectiveness of spironolactone as treatment of acne [Evidence Level: C].
Nast A, Dréno B, Bettoli V et al. European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad Dermatol Venereol 2012;26 Suppl 1:1-29. [PMID:22356611]
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