Evidence-Based Answers

Evidence Central™ is an integrated web and mobile solution that helps clinicians quickly answer etiology, diagnosis, treatment, and prognosis questions using the latest evidence-based research.

Browse

Evidence Central for Mobile Devices

Evidence Central iOS iPhone iPad Android

Evidence Central from Unbound Medicine, available for iOS® and Android™, is optimized for each platform and features superior navigation, so answers are easy to find at the bedside or anywhere they’re needed. Learn More

Word of the Day

Compression stockings prevent postthrombotic syndrome in patients with DVT

Clinical Question:
Does the use of venous compression stockings reduce the incidence of postthrombotic syndrome in patients with deep venous thrombosis?

Bottom Line:
In patients with deep venous thrombosis (DVT), the use of venous compression stockings decreases the risk of postthrombotic syndrome. However, the ideal type of stocking, as well as the ideal start time and duration of application, remain to be determined. (LOE = 1a-)

Reference:
Musani MH, Matta F, Yaekoub AY, Liang J, Hull RD, Stein PD. Venous compression for prevention of postthrombotic syndrome: a meta-analysis. Am J Med 2010;123(8):735-740.  [PMID:20670728]

Study Design:
Meta-analysis (randomized controlled trials)

Funding:
Unknown/not stated

Allocation:
Uncertain

Setting:
Various (meta-analysis)

Synopsis:
These authors searched PubMed and reviewed bibliographies from retrieved articles to identify randomized controlled trials that compared the use of compression stockings with no compression treatment to prevent postthrombotic syndrome in patients with DVT. Two authors independently assessed study eligibility. No quality assessment was performed. Combining data from the 5 included trials suggests that the use of venous compression reduces the incidence of postthrombotic syndrome (26% vs 46%; relative risk [RR] = 0.54; 95% CI, 0.44-0.67; P < .001). Mild to moderate postthrombotic syndrome was decreased from 37% to 22% (RR = 0.52; 0.40-0.67), while severe postthrombotic syndrome was decreased from 12% to 5% (RR = 0.38; 0.22-0.68). Overall, you would need to treat 5 patients with venous compression to prevent 1 episode of postthrombotic syndrome. Although there was no statistical heterogeneity detected, the studies were clinically heterogeneous in the characteristics of stockings used, time interval from diagnosis to application of stockings, duration of stocking use, and duration of follow-up.

RSS FEED

Site Licenses

Site license

Site Licenses are available for schools, universities, hospitals, government agencies, and companies. For more information, contact us.