EE+ POEM Archive
- WHO-recommended clinical signs are associated with clinical sepsis, culture-confirmed sepsis, and mortality in infants younger than 60 days
- 10-year all-cause mortality is similar for adults with left main disease treated with percutaneous coronary intervention vs coronary artery bypass grafting (NOBLE)
- Nirmatrelvir-ritonavir does not reduce hospitalizations but reduces duration of symptoms in low-ish risk population (PANORAMIC and CanTreatCOVID)
- Treatment of provoked vestibulodynia with electromyography-guided botulinum toxin injections modestly improves pain scores
- In patients with atherosclerosis, a low-density lipoprotein target of 55 mg/dL reduces cardiovascular events (number needed to treat = 30 over 3 years)
- Platelet-rich plasma injections = placebo for pain relief and functional improvement in adults with lateral epicondylitis
- Evolocumab reduces adverse cardiovascular events in high-risk adults unable to meet their lipid goals with statin therapy (VESALIUS-CV)
- Many patients informed of the absolute risk reduction with statin therapy would not choose to start treatment
- 2026 American Heart Association guidelines on diet to improve cardiovascular health
- Ten years after percutaneous coronary intervention, clopidogrel prevents more composite ischemic and bleeding events than aspirin
- Left atrial appendage closure is inferior to best medical therapy for patients with atrial fibrillation and high bleeding and stroke risk (CLOSURE-AF)
- Switching from diet soda to water consumption does not alter type 2 diabetes control (SODAS)
- In women with uncomplicated urinary tract infections, clinical and bacteriologic resolution occur more often with nitrofurantoin
- In patients with acute ischemic stroke or high-risk transient ischemic attack, asundexian reduces recurrent stroke with NNT = 71 (OCEANIC-STROKE)
- Bowel management alone is an effective first-line treatment for daytime urinary incontinence in children
- Fewer recurrent strokes with a triple pill added to standard blood pressure therapy after spontaneous intracerebral hemorrhage
- Cocoa extract very slightly decreases hsCRP levels and increases interferon-γ; has no known effect on clinical outcomes (COSMOS)
- Consider discontinuing levothyroxine in older adults, especially those who take 50 µg per day or less
- Increased noise and artificial light before bedtime is associated with reduced grades for children
- Smartphone AI app detects fetal movement more accurately than maternal perception
- Digital media counseling for families: Fewer strict rules, more discussion
- Oral microbiome therapy appears to be safe and effective in preventing short-term recurrences of C. difficile infection in adults