EE+ POEM Archive
- Tramadol: less effective with more adverse events than NSAIDs; no better than stronger opioids
- Surgery provides no additional benefit for shoulder impingement syndrome (FIMPACT)
- Urinary HPV testing is less sensitive than clinician sampling or self-cervical sampling in detecting cervical HPV or CIN2 or worse
- High-dose flu vaccine reduced hospitalizations slightly more than standard dose in one study (NNT = 1250) but not in another (GALFLU, DANFLU)
- Updated PECARN rule has high negative predictive value for ruling out bacterial meningitis in febrile infants
- Attention-deficit/hyperactivity disorder treatments can be selected on the basis of age group and relative benefit/harms
- Prophylactic antibiotic therapy associated with reduced incidence of significant wound complications after episiotomy or second-degree perineal tear
- At-home transcranial direct current stimulation is no more effective than placebo for moderate depression (PSYLECT)
- Systemic corticosteroids reduce mortality for adult patients hospitalized with community-acquired pneumonia in a low-resource setting
- Adults with PTSD not responding to SSRI treatment achieve better response by switching to an SNRI than by adding written exposure therapy (STEPS)
- Intranasal insulin decreases the duration of delirium in hospitalized older adults
- Elinzanetant (Lynkuet) reduces hot flashes and improves sleep quality in patients with menopause (OASIS-3)
- Similar mortality, less antibiotic exposure, and shorter length of stay with de-escalation of antibiotics for community-onset sepsis
- CBT-I is effective in adults with insomnia and chronic disease
- Risk-based mammography (with most women getting biennial screening starting at age 50) is noninferior to annual screening (WISDOM)
- One dose of HPV vaccine is noninferior to 2 doses at preventing HPV infection
- Norethindrone reduced prolonged bleeding related to etonogestrel implant (IMPLANET)
- People seem to prefer when physicians introduce themselves with their first and last names
- Adding antiplatelets to anticoagulants in adults with AF plus atherosclerosis and ischemic neurologic events: no additional benefit but more bleeding
- Passive infant immunization with nirsevimab is more effective than maternal RSV vaccine for lowering adverse RSV-related outcomes in newborns