EE+ POEM Archive
- Earlier initiation of anticoagulation associated with better outcomes in hospitalized patients with COVID-19
- Earlier thrombolysis, better outcome for stroke patients
- Early = delayed oxytocin for dysfunctional labor
- Early adenotonsillectomy and watchful waiting both options for children with sleep apnea
- Early angiography not crucial in low risk NSTEMI patients (TIMACS)
- Early anticoagulation after ischemic stroke is a safe strategy (ELAN)
- Early antiretrovirals prevent HIV transmission to partners
- Early antiretrovirals reduce mortality in HIV-infected infants (CHER)
- Early azithromycin prevents severe lower RTI in children with recurrent WARIs
- Early BP treatment for acute ischemic stroke has no impact on mortality or functional outcomes (CATIS-2)
- Early cardioversion no better than delayed cardioversion for recent-onset symptomatic atrial fibrillation
- Early cholecystectomy for mild gallstone pancreatitis shortens LOS
- Early cholecystectomy improves outcomes following mild gallstone pancreatitis more than delayed surgery
- Early CT angiography for suspected acute coronary syndrome reduces further ischemic testing; no effect on long-term clinical outcomes
- Early diabetes education has little effect (DESMOND)
- Early egg and peanut introduction reduces allergy risk; timing of gluten intro does not reduce risk of celiac disease
- Early endoscopy not needed in GERD without alarm symptoms
- Early endovenous ablation improves outcomes in patients with venous leg ulcers
- Early exercise improves return to function after ankle sprain
- Early feeding may benefit hospitalized patients with mild to moderate pancreatitis
- Early fibrinolysis effective in STEMI but causes more strokes (STREAM)
- Early goal-directed therapy using central venous hemodynamic targets in septic shock does not reduce deaths
- Early hydrocortisone ineffective in improving outcomes in patients with septic shock
- Early imaging for low back pain in elderly raises costs without improving quality
- Early initation of antiretrovirals recommended in HIV disease
- Early initiation of dialysis no better than delayed
- Early initiation of direct oral anticoagulants after acute stroke with atrial fibrillation is at least as good as later initiation
- Early initiation of RRT does not improve mortality in patients with sepsis and severe acute kidney injury
- Early initiation of RRT in critically ill patients with AKI does not lower 90-day mortality
- Early initiation of statins following ACS does not improve outcomes
- Early intervention may have a benefit for autistic disorder
- Early introduction of dietary gluten delays the diagnosis of celiac disease in breastfed infants (EAT)
- Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND)
- Early invasive therapy better for non-ST ACS
- Early motion + surgery = early motion + casting in Achilles rupture
- Early-onset preeclampsia associated with increased risk of critical congenital heart defects
- Early outpatient follow-up linked with fewer readmissions for COPD patients
- Early peanut consumption reduces the likelihood of later peanut allergy
- Early physical therapy for adults with acute low back pain is minimally effective
- Early predicts later weight gain with DMPA
- Early prenatal treatment of BV with clindamycin does not prevent late miscarriage or premature labor (PREMEVA)
- Early PT for acute low back pain is cost-effective, but gain in quality of life is likely too small to notice
- Early return to activity improves symptoms in children with concussion
- Early surgery reduces embolic events in patients with infective endocarditis
- Early switch to PO effective for severe CAP
- Early TIPS improves outcomes in cirrhotic patients with acute variceal bleeding
- Early tracheotomy ineffective at preventing ventilator-associated pneumonia in mechanically ventilated ICU patients
- Early treatment for PTSD
- Early treatment of gestational diabetes is modestly beneficial for neonatal and maternal outcomes
- Early treatment of screen-detected anal high-grade squamous intraepithelial lesions reduces progression to cancer
- Early tube feeding does not improve outcomes in acute pancreatitis
- Early vaccinations not associated with celiac disease
- Easy rule identifies patients with low-risk penicillin allergies
- Eating during labor doesn't affect outcomes
- Eating eggs is not associated with cardiovascular disease
- Ebola: 6- to 12-day incubation, fever, headache, weakness, dizziness, and diarrhea in most
- Echinacea is ineffective for reducing cold symptoms
- E-cigarettes more effective than nicotine replacement for cessation of tobacco use in adults
- E-cigarettes plus counseling may be minimally better than counseling alone for smoking cessation
- ED chest pain protocol is safe and efficient
- Edoxaban as effective as LMWH for treatment of cancer-associated VTE
- Edoxaban noninferior to warfarin for venous thromboembolism anticoagulation
- EEG inaccurate in diagnosing ADHD
- Effective methods for preventing pressure ulcers
- Effectiveness of aspirin in primary prevention appears to vary by patient weight
- Effective strategies for the prevention of preeclampsia and pregnancy-induced hypertension
- Effective systemic treatments for pyoderma gangrenosum
- Effective treatments for rosacea
- Effect of anacetrapib on patient-oriented outcomes remains uncertain
- Efpeglenatide reduces the risk of major adverse CV events in patients with T2DM + established CVD or chronic kidney disease (AMPLITUDE-O)
- Egg-allergic children can receive influenza vaccine
- eHealth program shortens sick leave after gynecological surgery
- Elagolix once-daily is associated with a reduction in heavy bleeding for women with leiomyomas
- Elagolix reduces pain but increases hot flushes/LDL and decreases BMD in women with mod-severe endometriosis
- Elagolix with add-back therapy effective for premenopausal heavy menstrual bleeding associated with fibroids
- Elbow/shoulder injections = NSAIDs short-term
- Elbow extension test rules out fracture
- Elderly patients with NSTEMI do better with invasive treatment (After Eighty)
- Elderly with higher BMI have lower mortality risk
- Elders want a say in when to stop cancer screenings
- Elective cesarean does not preserve anal continence
- Elective induction of labor at 39 weeks associated with decreased cesarean rate
- Electroacupuncture beneficial for women with stress urinary incontinence
- Electroacupuncture effective for chronic constipation
- Electroacupuncture for whiplash: slight decrease in pain, no change in disability or QOL
- Electroacupuncture is effective for insomnia treatment in adults with depression
- Electronic medication packaging devices of minimal benefit in improving compliance
- Electronic nicotine-delivery systems increase abstinence in tobacco users (NNT = 6 - 8)
- Elevated INR (> 1.5) at admission associated with increased mortality in hospitalized patients who use DOACs
- Eluxadoline marginally beneficial for IBS with diarrhea, but very expensive
- Emergency department clinicians overidentify drug-seeking behavior
- Emergency department management decreases A Fib admissions
- Emodepside highly effective against whipworm and hookworm in humans and appears safe
- Empagliflozin for acute myocardial infarction with increased risk of heart failure = fewer HF hospitalizations, no effect on mortality (EMPACT-MI)
- Empagliflozin reduces hospitalization for heart failure with preserved ejection fraction (NNT = 59 per year), but not mortality outcomes (EMPEROR-Preserved)
- Empagliflozin reduces hospitalizations for heart failure in patients with HF and a left ventricular ejection fraction < 30%
- Empagliflozin slows progression of renal disease in very high-risk patients with T2DM
- Empiric treatment of onychomycosis with terbinafine is most cost-effective strategy
- Endoanal application of nitroglycerin reduces headaches in treatment of chronic anal fissure
- Endocrine Society: Kids, and adults who are pregnant, have pre-diabetes, and are older than 74 years may benefit from empiric vitamin D
- End-of-rotation resident transitions assoc with greater mortality for hospitalized patients
- Endovascular AAA repair has better perioperative outcomes, similar long-term mortality, and higher long-term rupture rate
- Endovascular and open repairs have similar long-term mortality for AAA
- Endovascular denervation lowers blood pressure (RADIANCE-HTN SOLO)
- Endovascular therapies do not improve outcomes in acute stroke
- Endovascular therapy for ischemic stroke: better outcomes within 7 hours
- Endovascular therapy is effective for basilar artery occlusion in patients with moderate/severe symptoms (ATTENTION)
- Energy-absorbing/shunting hip protector does not reduce risk of fracture
- Enoxaparin > UFH for STEMI, with or without clopidogrel
- Enoxaparin > UFH for STEMI treated with fibrinolysis then PCI
- Enoxaparin better than aspirin for prevention of venous thromboembolism after total hip or knee arthroplasty
- Enoxaparin may lead to more bleeding in patients with moderate renal impairment
- Enterosgel effective for irritable bowel syndrome with diarrhea (NNT = 8)
- Enuresis alarm and desmopressin initially equal, but better long-term success with alarm
- Epicutaneous patch immunotherapy reduces severity of peanut allergy reactions and increases eliciting dose
- Epidural analgesia in labor is associated with lower rates of severe maternal morbidity
- Epidural steroid injection associated with abnormal uterine bleeding
- Epidural steroid injections ineffective for lumbar spinal stenosis
- Epidural steroid injections provide minimal, if any, benefit in low back pain with sciatica
- Epidural steroid not better than placebo injection for sciatica and spinal stenosis pain and function
- Epidural steroids for sciatica minimally effective in the short term
- Eplerenone no more effective than spironolactone, canrenone
- Eplerenone reduces mortality in NYHA II heart failure
- Epley maneuver effective in the long term for positional vertigo
- Epoetin alfa does not reduce transfusions in critically ill
- Equivalent mifepristone-misoprostol regimens for abortion
- Equivalent pain relief with different doses of ibuprofen
- Eradicating HP may reduce GERD symptoms
- Eradicating mold improves symptoms but not PFTs
- Erenumab decreases migraine frequency in patients who fail preventive therapies (LIBERTY)
- Erythropoiesis-stimulating agents increase risk of VTE/death in CA patients
- Erythropoiesis stimulation increases death risk in cancer patients
- Escitalopram, sertraline more effective, better tolerated than other newer antidepressants
- Escitalopram (Lexapro) minimally effective for generalized anxiety disorder in older adults
- Escitalopram (Lexapro) reduces risk of poststroke depression
- Escitalopram helpful for hot flashes
- Escitalopram not beneficial for patients with heart failure and depression (MOOD-HF)
- Escitalopram reduces risk of adverse cardiac events in adults with depression and acute coronary syndrome
- Esketamine is superior to quetiapine for remission of treatment-resistant depression (ESCAPE-TRD)
- Esomeprazole = placebo in preventing asthma exacerbations in pts with GERD Sx
- Esomeprazole doesn't improve asthma symptoms
- Esophageal cancer occurs in 7/1000 per year
- Essentially zero risk of HIV transmission from men who take antiretroviral therapy
- Estimate ultrasonographic liver size by multiplying physical exam size by 1.6
- Estrogen no better than vaginal lubricant for postmenopausal vaginal symptoms
- Estrogens following MI: questions remain
- ESWT improves chronic patella tendonitis
- Eszopiclone and escitalopram useful for anxiety and insomnia
- Etanercept effective for plaque psoriasis in children
- EULAR/ACR guideline on managing patients with polymyalgia rheumatica
- European guidelines on breast cancer screening 2020
- European Respiratory Society guidelines for hospitalized patients with COVID-19
- Evacetrapib increases HDL but does nothing for patient-oriented outcomes
- Even a small amount of maternal caffeine consumption is associated with decreased fetal growth
- Every other day use of rimegepant decreases migraine frequency by 1 per month
- Every-other-year FIT is at least as effective as a single sigmoidoscopy to detect colorectal cancer
- Evidence-based Delphi process for Barrett's esophagus management
- Evidence-based guideline for driving assessment of pts with dementia
- Evidence-based guideline for exercise-induced bronchospasm: pre-exercise SABA is still mainstay
- Evidence-based guideline for managing trigeminal neuralgia
- Evidence does not show benefit of treating mycoplasma pneumonia in children
- Evidence for combination antipyretics is limited
- Evidence inconclusive regarding artificial sweeteners and cancer risk
- Evidence is lacking for lifestyle interventions for obese pregnant women
- Evidence limited for hidradenitis suppurativa treatment; ATNF inhibitors may be helpful
- Evidence of benefit is lacking for low back pain relief with muscle relaxants
- Evolocumab provides a small reduction in need for revascularization (OSLER 1 and 2)
- Excess enoxaparin increases adverse outcomes in non-ST elevation ACS
- Excessive lowering of BP causes more harm than good
- Excess treatment with antibiotics for pneumonia is common and may lead to harm
- Exemestane reduces breast cancer risk in high-risk postmenopausal women
- Exemestane superior to tamoxifen in premenopausal women with breast cancer
- Exercise, but not vitamin D, decreases the risk of falls that cause injury in older women
- Exercise = knee surgery for degenerative meniscal tear
- Exercise alone and various combinations of interventions reduces the risk of injurious falls in older adults
- Exercise and diet good even for frail, obese elderly
- Exercise decreases depressive symptoms of chronic illness
- Exercise decreases falls and injuries in older people
- Exercise decreases falls in the elderly
- Exercise effective for depression in older people
- Exercise good for knee osteoarthritis symptoms and function
- Exercise improves/prevents postpartum depressive symptoms
- Exercise improves symptom control in IBS
- Exercise in healthy postmenopausal women lowers systolic and diastolic blood pressure by tiny amounts
- Exercise interventions in pregnancy modestly reduce weight gain
- Exercise prevents falls in elderly residents of care facilities while they are enrolled in exercise programs
- Expectant management after PPROM is beneficial for newborns
- Expectant management of hypertensive disorders less harmful for neonates until 37 weeks' gestation
- Expert panels: Continue opioids but increase monitoring for patients with cancer-related pain who also use nonmedical stimulants
- Explanation of depression as an adaptation to surroundings better accepted by patients than depression as a disease
- Exposure therapy superior to supportive counseling for sexual abuse–related PTSD in adolescent girls
- Exposure to dogs may reduce risk of atopic dermatitis in infants
- Expulsion rates of intrauterine devices placed postpartum vary based on several factors
- Extended anticoagulation may be helpul for patients with unprovoked VTE or PE
- Extended antiretroviral prophylaxis prevents HIV in breastfeeding infants
- Extended duration of letrozole for ER+ breast cancer reduces recurrence but not mortality
- Extended follow-up: anastrozole better than placebo to prevent breast cancer in high-risk women (IBIS-II)
- Extended PT reduces falls in elderly hip fracture patients
- Extended rivaroxaban prophylaxis following a medical inpatient stay does not provide a net benefit (MARINER)
- Extended study with a lower dose of steroids reports overall benefit for adults with IgA nephropathy
- Extended use of dabigatran no better than warfarin for high-risk pts after VTE; no net benefit vs placebo for avg-risk pts
- Extending dual antiplatelet therapy beyond 1 year is beneficial
- Extending the duration of prequit treatment with varenicline does not improve smoking quit rate
- Extensive intervention by hospital pharmacists led to decreased readmissions
- External cephalic version safe
- External cooling improves short-term outcomes in pts with septic shock
- Extracorporeal membrane oxygenation probably does not significantly reduce mortality in severe ARDS
- Extracranial-intracranial bypass surgery does not reduce recurrent stroke risk
- Extremely high HDL cholesterol associated with increased mortality in men and women
- Extremity nevus count associated with increased risk of melanoma and basal cell—but not squamous cell—carcinoma
- Ezetimibe does not slow progression of coronary disease (ENHANCE)