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Vitamin D does not affect isolated systolic hypertension

Clinical Question:
Does treatment with vitamin D lower blood pressure in older patients with isolated systolic hypertension and low vitamin D levels?

Bottom Line:
Vitamin D supplementation in patients with isolated systolic hypertension and low levels of vitamin D does not decrease systolic blood pressure after 1 year of treatment. (LOE = 1b)

Witham MD, Price RJ, Struthers AD, et al. Cholecalciferol treatment to reduce blood pressure in older patients with isolated systolic hypertension. A VitDISH randomized controlled trial. JAMA Intern Med doi:10.1001/jamainternmed.2013;9043. [Epub ahead of print]  [PMID:23939263]

Study Design:
Randomized controlled trial (double-blinded)



Outpatient (any)

Since low vitamin D levels are associated with hypertension, these Scottish researchers investigated the role of vitamin D supplementation in 159 patients, at least 70 years of age, with isolated systolic hypertension greater than 140 mmHg and vitamin D levels (25-hydroxyvitamin D) of less than 30 ng/mL (< 75 nm/L). Using concealed allocation, patients were randomized to receive oral placebo or cholecalciferol 100,000 units every 3 months for 1 year. As expected, vitamin D levels increased an average of 8 ng/mL (20 nm/L) in the treated patients. Systolic blood pressure, though, did not significantly change or differ between the groups (0.8 mmHg). Similarly, other measures -- 24-hour blood pressure, arterial stiffness, endothelial function -- did not change.


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